Mouse Bile Salt Export Pump (ABCB11) Protein
234€ (10 µg)
234€ (10 µg)
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935106861
info@markelab.com
name
Mouse Bile Salt Export Pump (ABCB11) Protein
category
Proteins and Peptides
provider
Abbexa
reference
abx167320
tested applications
WB, SDS-PAGE
Descripción del producto
ATP Binding Cassette Transporter B11 Protein is a recombinant Mouse protein expressed in E. coli.
Documents del producto
Instrucciones
Data sheet
Especificaciones del producto
| Alias | ABCB11,ABC16,BRIC2,BSEP,PFIC-2,PFIC2,PGY4,SPGP |
| Availability | Shipped within 5-7 working days. |
| Background | Protein ABCB11 |
| Buffer | Prior to lyophilization: PBS, pH 7.4, containing 0.01% Sarcosyl, 1 mM DTT, 5% Trehalose and Proclin-300. |
| Category | Proteins and Peptides |
| Conjugation | Unconjugated |
| Dry Ice | No |
| Expression | Recombinant |
| Form | Lyophilized To keep the original salt concentration, we recommend reconstituting to the original concentration prior to lyophilization (see Concentration) in ddH2O. If a lower concentration is required, dilute in PBS, pH 7.4. If a higher concentration is required, the product can be reconstituted directly in PBS, pH 7.4, though please note that this will change the overall salt concentration. The stock concentration should be between 0.1-1.0 mg/ml. Do not vortex. |
| Host | E. coli |
| Immunogen Target | Bile Salt Export Pump (ABCB11) |
| Name | Mouse Bile Salt Export Pump (ABCB11) Protein |
| Note | This product is for research use only. Not for human consumption, cosmetic, therapeutic or diagnostic use. |
| Observed MW | Molecular Weight: Calculated MW: 30.0 kDa Concentration: Prior to lyophilization: 200 µg/ml Sequence Fragment: Ile420-Leu656 Tag: N-terminal His tag |
| Origin | Mouse |
| Price | 234 |
| Provider | Abbexa |
| Purity | > 95% |
| Reference | abx167320 |
| Size 1 | 10 µg |
| Size 2 | 50 µg |
| Size 3 | 100 µg |
| Size 4 | 200 µg |
| Size 5 | 500 µg |
| Status | RUO |
| Storage | Store at 2-8 °C for up to one month. Store at -80 °C for up to one year. Avoid repeated freeze/thaw cycles. |
| Tested Applications | WB, SDS-PAGE |
| UniProt ID | Q9QY30 |
Descripcion del producto en español
Background en español
ABCB11, also known as the bile salt export pump (BSEP), is an essential transporter located on the canalicular membrane of hepatocytes. It is responsible for exporting bile salts from the liver into bile, a critical step in the digestion and absorption of dietary fats and the excretion of waste products. ABCB11 is ATP-dependent and plays a vital role in maintaining bile flow and preventing bile salt accumulation, which can damage liver cells. Mutations in the ABCB11 gene are associated with progressive familial intrahepatic cholestasis type 2 (PFIC2), a severe liver disorder characterized by impaired bile salt secretion and liver damage. Dysregulation or inhibition of ABCB11 is also implicated in drug-induced cholestasis and liver injury. Its essential function in bile production and liver health makes it a critical target for understanding and treating cholestatic diseases.
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