Bile Salt Export Pump (ABCB11) Antibody
286€ (100 µl)
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935106861
info@markelab.com
name
Bile Salt Export Pump (ABCB11) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx130560
tested applications
IHC
Description
ABCB11 Antibody is a Rabbit Polyclonal against ABCB11.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Target: Bile Salt Export Pump (ABCB11) Immunogen: abx650390 - Recombinant ABCB11 (Glu421-Ala663) expressed in E. coli |
| Host | Rabbit |
| Reactivity | Human |
| Assay Type | Concentration: 0.41 mg/ml |
| Recommended Dilution | WB (Predicted): 0.01-2 µg/ml, IHC: 5-20 µg/ml, IF/ICC (Predicted): 5-20 µg/ml. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Purification | Purified by antigen-specific affinity chromatography, followed by Protein A affinity chromatography. |
| Size 1 | 100 µl |
| Size 2 | 200 µl |
| Size 3 | 1 ml |
| Form | Liquid |
| Tested Applications | IHC |
| Buffer | 0.01 M PBS, pH 7.4, containing 0.05% Proclin-300, 50% glycerol. |
| Availability | Shipped within 5-7 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | O95342 |
| Alias | ABCB11,ABC16,BRIC2,BSEP,PFIC-2,PFIC2,PGY4,SPGP |
| Background | Antibody anti-ABCB11 |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |
Descripción
ABCB11, also known as the bile salt export pump (BSEP), is an essential transporter located on the canalicular membrane of hepatocytes. It is responsible for exporting bile salts from the liver into bile, a critical step in the digestion and absorption of dietary fats and the excretion of waste products. ABCB11 is ATP-dependent and plays a vital role in maintaining bile flow and preventing bile salt accumulation, which can damage liver cells. Mutations in the ABCB11 gene are associated with progressive familial intrahepatic cholestasis type 2 (PFIC2), a severe liver disorder characterized by impaired bile salt secretion and liver damage. Dysregulation or inhibition of ABCB11 is also implicated in drug-induced cholestasis and liver injury. Its essential function in bile production and liver health makes it a critical target for understanding and treating cholestatic diseases.
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Human Bile Salt Export Pump (ABCB11) Protein
Human ABCB11 Protein is a recombinant Human protein expressed in E. coli.
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