Mouse ATP-Dependent Translocase ABCB1 (ABCB1) ELISA Kit
643.5€ (96 tests)
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935106861
info@markelab.com
name
Mouse ATP-Dependent Translocase ABCB1 (ABCB1) ELISA Kit
category
ELISA Kits
provider
Abbexa
reference
abx154538
tested applications
ELISA
Description
Mouse ATP-Dependent Translocase ABCB1 (ABCB1) ELISA Kit is an ELISA Kit for the in vitro quantitative measurement of Mouse ATP-Dependent Translocase ABCB1 (ABCB1) concentrations in tissue homogenates and other biological fluids. This assay has high sensitivity and excellent specificity for detection of P-glycoprotein 1
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | ELISA Kits |
| Immunogen Target | ATP-Dependent Translocase ABCB1 (ABCB1) |
| Reactivity | Mouse |
| Detection Method | Colorimetric |
| Assay Data | Quantitative |
| Assay Type | Sandwich |
| Test Range | 0.156 ng/ml - 10 ng/ml |
| Sensitivity | < 0.06 ng/ml |
| Recommended Dilution | Optimal dilutions/concentrations should be determined by the end user. |
| Size 1 | 96 tests |
| Size 2 | 5 × 96 tests |
| Size 3 | 10 × 96 tests |
| Form | Lyophilized |
| Tested Applications | ELISA |
| Sample Type | Tissue homogenates and other biological fluids. |
| Availability | Shipped within 5-7 working days. The validity for this kit is at least 6 months. Up to 12 months validity can be provided on request. |
| Storage | Shipped at 4 °C. Upon receipt, store the kit according to the storage instruction in the kit's manual. |
| Dry Ice | No |
| UniProt ID | P06795 |
| Gene ID | 18669 |
| Alias | ABC20,CD243,CLCS,GP170,MDR1,P-GP,PGY1,p-170 |
| Background | Elisa kits for ABCB1 |
| Status | RUO |
| Note | Validity: The validity for this kit is at least 6 months. Up to 12 months validity can be provided on request. This product is for research use only. The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments. Please note that our ELISA and CLIA kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein. |
Descripción
ABCB1, also known as P-glycoprotein, is a well-studied ATP-dependent efflux transporter involved in the transport of a wide range of substrates, including drugs, lipids, and xenobiotics. It is highly expressed in barrier tissues, such as the blood-brain barrier, intestines, liver, and kidneys, where it functions to protect tissues by actively exporting toxic compounds and drugs. ABCB1 plays a crucial role in pharmacokinetics, influencing drug absorption, distribution, and elimination. Overexpression of ABCB1 in cancer cells is a major contributor to multidrug resistance, as it pumps chemotherapeutic agents out of cells, reducing their efficacy. Structurally, ABCB1 contains two transmembrane domains and two ATP-binding domains, which utilize ATP hydrolysis to drive substrate transport. Its pivotal role in drug resistance and detoxification makes it a significant target in cancer therapy and pharmacological research.
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