Mouse ATP-Dependent Translocase ABCB1 (ABCB1) ELISA Kit

Este producto es parte de ABCB - ATP binding cassette subfamily B member
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643.5€ (96 tests)

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935106861
info@markelab.com
name
Mouse ATP-Dependent Translocase ABCB1 (ABCB1) ELISA Kit
category
ELISA Kits
provider
Abbexa
reference
abx154538
tested applications
ELISA

Description

Mouse ATP-Dependent Translocase ABCB1 (ABCB1) ELISA Kit is an ELISA Kit for the in vitro quantitative measurement of Mouse ATP-Dependent Translocase ABCB1 (ABCB1) concentrations in tissue homogenates and other biological fluids. This assay has high sensitivity and excellent specificity for detection of P-glycoprotein 1

Documents del producto

Instrucciones
Data sheet
Descargar

Product specifications

Category
ELISA Kits
Immunogen Target
ATP-Dependent Translocase ABCB1 (ABCB1)
Reactivity
Mouse
Detection Method
Colorimetric
Assay Data
Quantitative
Assay Type
Sandwich
Test Range
0.156 ng/ml - 10 ng/ml
Sensitivity
< 0.06 ng/ml
Recommended Dilution
Optimal dilutions/concentrations should be determined by the end user.
Size 1
96 tests
Size 2
5 × 96 tests
Size 3
10 × 96 tests
Form
Lyophilized
Tested Applications
ELISA
Sample Type
Tissue homogenates and other biological fluids.
Availability
Shipped within 5-7 working days. The validity for this kit is at least 6 months. Up to 12 months validity can be provided on request.
Storage
Shipped at 4 °C. Upon receipt, store the kit according to the storage instruction in the kit's manual.
Dry Ice
No
UniProt ID
P06795
Gene ID
18669
Alias
ABC20,CD243,CLCS,GP170,MDR1,P-GP,PGY1,p-170
Background
Elisa kits for ABCB1
Status
RUO
Note
Validity: The validity for this kit is at least 6 months. Up to 12 months validity can be provided on request.
This product is for research use only.   The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments.   Please note that our ELISA and CLIA kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein.

Descripción

ABCB1, also known as P-glycoprotein, is a well-studied ATP-dependent efflux transporter involved in the transport of a wide range of substrates, including drugs, lipids, and xenobiotics. It is highly expressed in barrier tissues, such as the blood-brain barrier, intestines, liver, and kidneys, where it functions to protect tissues by actively exporting toxic compounds and drugs. ABCB1 plays a crucial role in pharmacokinetics, influencing drug absorption, distribution, and elimination. Overexpression of ABCB1 in cancer cells is a major contributor to multidrug resistance, as it pumps chemotherapeutic agents out of cells, reducing their efficacy. Structurally, ABCB1 contains two transmembrane domains and two ATP-binding domains, which utilize ATP hydrolysis to drive substrate transport. Its pivotal role in drug resistance and detoxification makes it a significant target in cancer therapy and pharmacological research.

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