935106861
info@markelab.com
Precio
812.5€ (96 tests)
Mouse ATP-Dependent Translocase ABCB1 (ABCB1) Protein Chemiluminescent Immunoassay (CLIA) Kit is a Sandwich Chemiluminescent Immunoassay (CLIA) Kit for use with Tissue homogenates, cell lysates and other biological fluids.
Mouse Permeability Glycoprotein (Pgp) CLIA Kit is a Sandwich CLIA Kit for use with Tissue homogenates, cell lysates and other biological fluids.
ABCB1, also known as P-glycoprotein, is a well-studied ATP-dependent efflux transporter involved in the transport of a wide range of substrates, including drugs, lipids, and xenobiotics. It is highly expressed in barrier tissues, such as the blood-brain barrier, intestines, liver, and kidneys, where it functions to protect tissues by actively exporting toxic compounds and drugs. ABCB1 plays a crucial role in pharmacokinetics, influencing drug absorption, distribution, and elimination. Overexpression of ABCB1 in cancer cells is a major contributor to multidrug resistance, as it pumps chemotherapeutic agents out of cells, reducing their efficacy. Structurally, ABCB1 contains two transmembrane domains and two ATP-binding domains, which utilize ATP hydrolysis to drive substrate transport. Its pivotal role in drug resistance and detoxification makes it a significant target in cancer therapy and pharmacological research.
CLIA Kits
ATP-Dependent Translocase ABCB1 (ABCB1)
Mouse
0.156 ng/ml - 10 ng/ml
< 0.06 ng/ml
Sandwich
Quantitative
Chemiluminescent
Tissue homogenates, cell lysates and other biological fluids.
96 tests
5 × 96 tests
10 × 96 tests
ABC20,CD243,CLCS,GP170,MDR1,P-GP,PGY1,p-170
Enviado a 4 °C. Una vez recibido, almacene el kit de acuerdo con las instrucciones citadas en el manual del kit
ABCB1
No
El rango y la sensibilidad pueden variar. Le recomendamos contactar con nosotros a fin de obtener la última información sobre posibles actualizaciones, que no estén representadas en este catalogo. Si necesita un rango específico, contáctenos y trataremos de ayudarle. Consulte sobre posible información que pueda ayudarle a elegir la dilución apropiada para sus muestras. Los kits CLIA están optimizados para la detección de muestras nativas, las proteínas recombinantes, pueden resultar problemáticas a causa de diferencias en la secuencia o cambios en la estructura terciaria.
Precio a consultar
Ver másPrecio a consultar
Ver másPrecio a consultar
Ver más