Mouse ATP Binding Cassette Transporter D4 (ABCD4) Protein
221€ (10 µg)
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935106861
info@markelab.com
name
Mouse ATP Binding Cassette Transporter D4 (ABCD4) Protein
category
Proteins and Peptides
provider
Abbexa
reference
abx650405
tested applications
WB, SDS-PAGE
Description
Mouse ABCD4 Protein is a recombinant Mouse protein produced in a Prokaryotic expression system (E. coli).
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Proteins and Peptides |
| Immunogen Target | ATP Binding Cassette Transporter D4 (ABCD4) |
| Host | E. coli |
| Origin | Mouse |
| Conjugation | Unconjugated |
| Observed MW | Molecular Weight: Calculated MW: 31.6 kDa Concentration: Prior to lyophilization: 200 µg/ml Sequence Fragment: Arg356-Glu606 Tag: N-terminal His tag |
| Expression | Recombinant |
| Purity | > 95% |
| Size 1 | 10 µg |
| Size 2 | 50 µg |
| Size 3 | 100 µg |
| Size 4 | 200 µg |
| Size 5 | 500 µg |
| Form | Lyophilized To keep the original salt concentration, we recommend reconstituting to the original concentration prior to lyophilization (see Concentration) in ddH2O. If a lower concentration is required, dilute in PBS, pH 7.4. If a higher concentration is required, the product can be reconstituted directly in PBS, pH 7.4, though please note that this will change the overall salt concentration. The stock concentration should be between 0.1-1.0 mg/ml. Do not vortex. |
| Tested Applications | WB, SDS-PAGE |
| Buffer | Prior to lyophilization: PBS, pH 7.4, containing 0.01% Sarcosyl, 1 mM DTT, 5% Trehalose and Proclin-300. |
| Availability | Shipped within 5-7 working days. |
| Storage | Store at 2-8 °C for up to one month. Store at -80 °C for up to one year. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | O89016 |
| Alias | ABC41,EST352188,MAHCJ,P70R,P79R |
| Background | Protein ABCD4 |
| Status | RUO |
| Note | This product is for research use only. Not for human consumption, cosmetic, therapeutic or diagnostic use. |
Descripción
ABCD4 is a peroxisomal and lysosomal ATP-binding cassette transporter that facilitates the transport of vitamin B12 (cobalamin) across intracellular membranes, enabling its proper processing and utilization. ABCD4 works in conjunction with lysosomal proteins such as LMBD1 to release vitamin B12 from lysosomes into the cytosol, where it is converted into its active forms, methylcobalamin and adenosylcobalamin, essential for DNA synthesis and energy metabolism. Mutations in ABCD4 are associated with cobalamin deficiency type F, which leads to megaloblastic anemia, neurological symptoms, and other metabolic abnormalities. ABCD4 is expressed in various tissues, with critical roles in maintaining vitamin B12 homeostasis and supporting metabolic pathways dependent on this essential cofactor.
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