ATP Binding Cassette Transporter D4 (ABCD4) Antibody
286€ (100 µl)
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935106861
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name
ATP Binding Cassette Transporter D4 (ABCD4) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx130577
tested applications
WB, IHC, IF/ICC
Description
ABCD4 Antibody is a Rabbit Polyclonal against ABCD4.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | ATP Binding Cassette Transporter D4 (ABCD4) |
| Host | Rabbit |
| Reactivity | Mouse |
| Recommended Dilution | WB: 0.01-2 µg/ml, IHC: 5-20 µg/ml, IF/ICC: 5-20 µg/ml. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Purification | Purified by antigen-specific affinity chromatography, followed by Protein A affinity chromatography. |
| Size 1 | 100 µl |
| Size 2 | 200 µl |
| Size 3 | 1 ml |
| Form | Liquid |
| Tested Applications | WB, IHC, IF/ICC |
| Buffer | 0.01 M PBS, pH 7.4, containing 0.05% Proclin-300, 50% glycerol. |
| Availability | Shipped within 5-7 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| Alias | ABC41,EST352188,MAHCJ,P70R,P79R |
| Background | Antibody anti-ABCD4 |
| Status | RUO |
Descripción
ABCD4 is a peroxisomal and lysosomal ATP-binding cassette transporter that facilitates the transport of vitamin B12 (cobalamin) across intracellular membranes, enabling its proper processing and utilization. ABCD4 works in conjunction with lysosomal proteins such as LMBD1 to release vitamin B12 from lysosomes into the cytosol, where it is converted into its active forms, methylcobalamin and adenosylcobalamin, essential for DNA synthesis and energy metabolism. Mutations in ABCD4 are associated with cobalamin deficiency type F, which leads to megaloblastic anemia, neurological symptoms, and other metabolic abnormalities. ABCD4 is expressed in various tissues, with critical roles in maintaining vitamin B12 homeostasis and supporting metabolic pathways dependent on this essential cofactor.
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