Mouse ATP Binding Cassette Transporter B4 (ABCB4) Protein

Este producto es parte de ABCB - ATP binding cassette subfamily B member
Mouse ATP Binding Cassette Transporter B4 (ABCB4) Protein

Pida mas información

935106861

info@markelab.com

Precio

221€ (10 µg)

Protein ABCB4

proveedor

Abbexa

reference

abx650379

Tested Applications

WB, SDS-PAGE

reactivity

status

RUO

clonality

Descripción

Mouse ATP Binding Cassette Transporter B4 (ABCB4) Protein is a recombinant Mouse protein produced in a Prokaryotic expression system (E. coli).


Background

ABCB4, also known as MDR3, is expressed on the canalicular membrane of hepatocytes and plays a pivotal role in bile formation by mediating the ATP-dependent translocation of phosphatidylcholine into bile. Phosphatidylcholine protects bile ducts from the detergent effects of bile salts, ensuring proper bile composition and preventing bile-related liver damage. Mutations in ABCB4 are associated with progressive familial intrahepatic cholestasis type 3 (PFIC3), low phospholipid-associated cholelithiasis (LPAC), and other cholestatic liver diseases. Dysregulation of ABCB4 leads to bile duct injury, inflammation, and fibrosis, ultimately resulting in liver dysfunction. As a critical regulator of bile composition, ABCB4 is a significant focus in the study of liver health and diseases related to bile metabolism.

Características del producto

category

Proteins and Peptides


origin

Mouse


host

E. coli


immunogen target

ATP Binding Cassette Transporter B4 (ABCB4)


host

E. coli


conjugation

Unconjugated


form

Lyophilized To keep the original salt concentration, we recommend reconstituting to the original concentration prior to lyophilization (see Concentration) in ddH2O. If a lower concentration is required, dilute in PBS, pH 7.4. If a higher concentration is required, the product can be reconstituted directly in PBS, pH 7.4, though please note that this will change the overall salt concentration. The stock concentration should be between 0.1-1.0 mg/ml. Do not vortex.


tested applications

WB, SDS-PAGE


size 1

10 µg


size 2

50 µg


size 3

100 µg


size 4

200 µg


size 5

500 µg


observerd MW

Molecular Weight: Calculated MW: 30.3 kDa Concentration: Prior to lyophilization: 200 µg/ml Sequence Fragment: Asn1034-Leu1276 Tag: N-terminal His tag


expression

Recombinant


purity

> 95%


buffer

Prior to lyophilization: PBS, pH 7.4, containing 0.01% Sarcosyl, 1 mM DTT, 5% Trehalose and Proclin-300.


storage

Store at 2-8 °C for up to one month. Store at -80 °C for up to one year. Avoid repeated freeze/thaw cycles.


or code

ABCB4


dry ice

No


availability

Shipped within 5-7 working days.


alias

ABC21,GBD1,ICP3,MDR2,MDR2/3,MDR3,PFIC-3,PGY3


note

This product is for research use only. Not for human consumption, cosmetic, therapeutic or diagnostic use.


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