ATP Binding Cassette Transporter B4 (ABCB4) Antibody (FITC)
169€ (20 µg)
Por favor contáctenos para obtener información detallada sobre el precio y disponibilidad.
935106861
info@markelab.com
name
ATP Binding Cassette Transporter B4 (ABCB4) Antibody (FITC)
category
Primary Antibodies
provider
Abbexa
reference
abx107097
Description
ATP Binding Cassette Transporter B4 (ABCB4) Antibody (FITC) is a Rabbit Polyclonal antibody against ATP Binding Cassette Transporter B4 (ABCB4) conjugated to FITC.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Target: ATP Binding Cassette Transporter B4 (ABCB4) Immunogen: Recombinant mouse Multidrug resistance protein 3 protein (352-708AA). |
| Host | Rabbit |
| Reactivity | Mouse |
| Detection Method | Laser Line: 488 Excitation/Emission: 499/515 |
| Recommended Dilution | Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | FITC |
| Isotype | IgG |
| Purity | > 95% |
| Purification | Purified by Protein G. |
| Size 1 | 20 µg |
| Size 2 | 50 µg |
| Size 3 | 100 µg |
| Size 4 | 200 µg |
| Size 5 | 1 mg |
| Form | Liquid |
| Buffer | 0.01 M PBS, pH 7.4, 0.03% Proclin-300 and 50% Glycerol. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid exposure to light. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | P21440 |
| Gene ID | 18670 |
| Alias | ABC21,GBD1,ICP3,MDR2,MDR2/3,MDR3,PFIC-3,PGY3 |
| Background | Antibody anti-ABCB4 |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |
Descripción
ABCB4, also known as MDR3, is expressed on the canalicular membrane of hepatocytes and plays a pivotal role in bile formation by mediating the ATP-dependent translocation of phosphatidylcholine into bile. Phosphatidylcholine protects bile ducts from the detergent effects of bile salts, ensuring proper bile composition and preventing bile-related liver damage. Mutations in ABCB4 are associated with progressive familial intrahepatic cholestasis type 3 (PFIC3), low phospholipid-associated cholelithiasis (LPAC), and other cholestatic liver diseases. Dysregulation of ABCB4 leads to bile duct injury, inflammation, and fibrosis, ultimately resulting in liver dysfunction. As a critical regulator of bile composition, ABCB4 is a significant focus in the study of liver health and diseases related to bile metabolism.
Related Products
Human ABCB4 (Multidrug resistance protein 3) ELISA Kit
Ver Producto
Human ABCB4 (Multidrug resistance protein 3) QuickTest ELISA Kit
Ver Producto
ATP Binding Cassette Transporter B4 (ABCB4) Antibody (Biotin)
ATP Binding Cassette Transporter B4 (ABCB4) Antibody (Biotin) is a Rabbit Polyclonal antibody against ATP Binding Cassette Transporter B4 (ABCB4) conjugated to Biotin.
Ver Producto