Mouse ATP Binding Cassette Subfamily A Member 8 (ABCA8) Protein
221€ (10 µg)
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935106861
info@markelab.com
name
Mouse ATP Binding Cassette Subfamily A Member 8 (ABCA8) Protein
category
Proteins and Peptides
provider
Abbexa
reference
abx650397
tested applications
WB, SDS-PAGE
Description
Mouse ABCA8 Protein is a recombinant Mouse protein produced in a Prokaryotic expression system (E. coli).
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Proteins and Peptides |
| Immunogen Target | ATP Binding Cassette Subfamily A Member 8 (ABCA8) |
| Host | E. coli |
| Origin | Mouse |
| Conjugation | Unconjugated |
| Observed MW | Molecular Weight: Calculated MW: 26.7 kDa Concentration: Prior to lyophilization: 200 µg/ml Sequence Fragment: Ala1303-Glu1514 Tag: N-terminal His tag |
| Expression | Recombinant |
| Purity | > 95% |
| Size 1 | 10 µg |
| Size 2 | 50 µg |
| Size 3 | 100 µg |
| Size 4 | 200 µg |
| Size 5 | 500 µg |
| Form | Lyophilized To keep the original salt concentration, we recommend reconstituting to the original concentration prior to lyophilization (see Concentration) in ddH2O. If a lower concentration is required, dilute in PBS, pH 7.4. If a higher concentration is required, the product can be reconstituted directly in PBS, pH 7.4, though please note that this will change the overall salt concentration. The stock concentration should be between 0.1-1.0 mg/ml. Do not vortex. |
| Tested Applications | WB, SDS-PAGE |
| Buffer | Prior to lyophilization: PBS, pH 7.4, containing 0.01% Sarcosyl, 1 mM DTT, 5% Trehalose and Proclin-300. |
| Availability | Shipped within 5-7 working days. |
| Storage | Store at 2-8 °C for up to one month. Store at -80 °C for up to one year. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | Q8K440 |
| Alias | KIAA0822 |
| Background | Protein ABCA8 |
| Status | RUO |
| Note | This product is for research use only. Not for human consumption, cosmetic, therapeutic or diagnostic use. |
Descripción
ABCA8 is a member of the ATP-binding cassette transporter family, primarily involved in lipid transport and xenobiotic metabolism. It is highly expressed in the brain, liver, and kidneys, suggesting roles in lipid homeostasis and the clearance of toxins or drugs. ABCA8 is thought to facilitate the transport of cholesterol and sphingolipids across cellular membranes, contributing to cellular lipid regulation. In the brain, ABCA8 has been implicated in myelin formation and neuronal maintenance, where dysregulation may contribute to neurodegenerative diseases. Mutations or altered expression of ABCA8 have been associated with conditions such as multiple sclerosis and certain cancers. Its role in lipid metabolism and potential involvement in drug resistance highlight its importance in both physiological and pathological processes.
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