ATP Binding Cassette Subfamily A Member 8 (ABCA8) Antibody
52€ (10 µg)
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935106861
info@markelab.com
name
ATP Binding Cassette Subfamily A Member 8 (ABCA8) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx014228
tested applications
ELISA, WB
Description
Rabbit polyclonal antibody against ABCA8 protein. Immunogen region is Internal.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | ATP Binding Cassette Subfamily A Member 8 (ABCA8) |
| Host | Rabbit |
| Reactivity | Human, Mouse |
| Recommended Dilution | WB: 1/500 - 1/3000, ELISA: 1/40000. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Purified from rabbit antiserum by affinity chromatography using epitope-specific immunogen. |
| Size 1 | 10 µg |
| Size 2 | 100 µg |
| Size 3 | 200 µg |
| Size 4 | 300 µg |
| Size 5 | 1 mg |
| Form | Liquid |
| Tested Applications | ELISA, WB |
| Buffer | PBS (without Mg<sup>2+</sup> and Ca<sup>2+</sup>), pH 7.4, 150 mM NaCl, 0.02% sodium azide, 50% glycerol. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | O94911 |
| Alias | KIAA0822 |
| Background | Antibody anti-ABCA8 |
| Status | RUO |
| Note | Concentration: 1 mg/ml - |
Descripción
ABCA8 is a member of the ATP-binding cassette transporter family, primarily involved in lipid transport and xenobiotic metabolism. It is highly expressed in the brain, liver, and kidneys, suggesting roles in lipid homeostasis and the clearance of toxins or drugs. ABCA8 is thought to facilitate the transport of cholesterol and sphingolipids across cellular membranes, contributing to cellular lipid regulation. In the brain, ABCA8 has been implicated in myelin formation and neuronal maintenance, where dysregulation may contribute to neurodegenerative diseases. Mutations or altered expression of ABCA8 have been associated with conditions such as multiple sclerosis and certain cancers. Its role in lipid metabolism and potential involvement in drug resistance highlight its importance in both physiological and pathological processes.
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