ATP Binding Cassette Subfamily A Member 8 (ABCA8) Antibody

Background

ABCA8 is a member of the ATP-binding cassette transporter family, primarily involved in lipid transport and xenobiotic metabolism. It is highly expressed in the brain, liver, and kidneys, suggesting roles in lipid homeostasis and the clearance of toxins or drugs. ABCA8 is thought to facilitate the transport of cholesterol and sphingolipids across cellular membranes, contributing to cellular lipid regulation. In the brain, ABCA8 has been implicated in myelin formation and neuronal maintenance, where dysregulation may contribute to neurodegenerative diseases. Mutations or altered expression of ABCA8 have been associated with conditions such as multiple sclerosis and certain cancers. Its role in lipid metabolism and potential involvement in drug resistance highlight its importance in both physiological and pathological processes.