Mouse Anaphase-promoting complex subunit 11 (ANAPC11) ELISA Kit
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935106861
info@markelab.com
Precio
715€ (96 tests)
Elisa kits for ANAPC11
proveedor
Abbexareference
abx502107Tested Applications
ELISAreactivity
Mousestatus
RUOclonality
Descripción
Mouse Anaphase-promoting complex subunit 11 (ANAPC11) ELISA Kit is an ELISA Kit for the in vitro quantitative measurement of Mouse Anaphase-promoting complex subunit 11 concentrations in tissue homogenates, cell lysates and other biological fluids.
Background
ANAPC11 is the catalytic RING finger subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C), where it facilitates the ubiquitin transfer activity of the complex. As an E3 ubiquitin ligase, ANAPC11 directly interacts with E2 ubiquitin-conjugating enzymes to catalyze the ubiquitination of cell cycle regulators such as cyclin B and securin, promoting their degradation via the proteasome. This process is critical for initiating anaphase, regulating mitotic exit, and maintaining genomic stability. ANAPC11 is essential for APC/C activity, and its loss or inhibition results in mitotic arrest, aneuploidy, and cell cycle defects. Mutations or dysregulation of ANAPC11 have been associated with cancer progression, as impaired proteolysis of APC/C substrates can lead to uncontrolled proliferation and chromosomal instability. ANAPC11’s catalytic function makes it a central component of APC/C and a potential target for cancer therapies aimed at disrupting mitotic progression in tumor cells.
Características del producto
category
ELISA Kits
immunogen target
Anaphase-promoting complex subunit 11 (ANAPC11)
reactivity
Mouse
test range
0.156 ng/ml - 10 ng/ml
assay data
Quantitative
form
Lyophilized
detection method
Colorimetric
sample type
Tissue homogenates, cell lysates and other biological fluids.
size 1
96 tests
alias
ANAPC11,HSPC214,Cyclosome subunit 11
storage
Shipped at 4 °C. Upon receipt, store the kit according to the storage instruction in the kit's manual.
or code
ANAPC11
dry ice
No
uniprot id
note
This product is for research use only. The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments. Please note that our ELISA and CLIA kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein.
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