Anaphase-Promoting Complex Subunit 11 (ANAPC11) Antibody
383.5€ (100 µl)
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935106861
info@markelab.com
name
Anaphase-Promoting Complex Subunit 11 (ANAPC11) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx224348
tested applications
ELISA, WB, FCM
Description
ANAPC11 Antibody is a Mouse Monoclonal against ANAPC11.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Anaphase-Promoting Complex Subunit 11 (ANAPC11) |
| Host | Mouse |
| Reactivity | Human, Mouse |
| Recommended Dilution | ELISA: 1/10000, WB: 1/500 - 1/2000, FCM: 1/200 - 1/400. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Monoclonal |
| Isotype | IgG2a |
| Purification | Purified from ascites by Protein G chromatography. |
| Size 1 | 100 µl |
| Form | Liquid |
| Tested Applications | ELISA, WB, FCM |
| Buffer | PBS, containing 0.05% sodium azide. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | O75469 |
| Gene ID | 8856 |
| OMIM | 603065 |
| Alias | ANAPC11,HSPC214,Cyclosome subunit 11 |
| Background | Antibody anti-ANAPC11 |
| Status | RUO |
| Note | Concentration: 1 mg/ml - |
Descripción
ANAPC11 is the catalytic RING finger subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C), where it facilitates the ubiquitin transfer activity of the complex. As an E3 ubiquitin ligase, ANAPC11 directly interacts with E2 ubiquitin-conjugating enzymes to catalyze the ubiquitination of cell cycle regulators such as cyclin B and securin, promoting their degradation via the proteasome. This process is critical for initiating anaphase, regulating mitotic exit, and maintaining genomic stability. ANAPC11 is essential for APC/C activity, and its loss or inhibition results in mitotic arrest, aneuploidy, and cell cycle defects. Mutations or dysregulation of ANAPC11 have been associated with cancer progression, as impaired proteolysis of APC/C substrates can lead to uncontrolled proliferation and chromosomal instability. ANAPC11’s catalytic function makes it a central component of APC/C and a potential target for cancer therapies aimed at disrupting mitotic progression in tumor cells.
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