Mouse Amyloid beta 40 (Abeta40) CLIA Kit
643.5€ (96 tests)
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name
Mouse Amyloid beta 40 (Abeta40) CLIA Kit
category
CLIA Kits
provider
Abbexa
reference
abx196712
tested applications
CLIA
Description
Mouse Amyloid Beta 40 (Ab40) Chemiluminescent Immunoassay (CLIA) Kit is a Chemiluminescent Immunoassay (CLIA) kit against Amyloid Beta 40 (Ab40).
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | CLIA Kits |
| Immunogen Target | Amyloid beta 40 (Abeta40) |
| Reactivity | Mouse |
| Detection Method | Chemiluminescent |
| Assay Data | Quantitative |
| Test Range | 15.6 pg/ml - 1000 pg/ml |
| Sensitivity | 9.38 pg/ml |
| Recommended Dilution | Optimal dilutions/concentrations should be determined by the end user. |
| Size 1 | 96 tests |
| Form | Lyophilized |
| Tested Applications | CLIA |
| Sample Type | Serum, plasma and other biological fluids. |
| Availability | Shipped within 5-12 working days. |
| Storage | Shipped at 4 °C. Upon receipt, store the kit according to the storage instruction in the kit's manual. |
| Dry Ice | No |
| Alias | Aβ40|Amyloid Beta 40|Abeta 40|Beta-amyloid protein 40|Aβ|1-40 |
| Background | CLIA Kits Abeta40 |
| Status | RUO |
| Note | The validity for this kit is 6 months. This product is for research use only. The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments. Please note that our ELISA and CLIA kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein. |
Descripción
Abeta40 is a 40-amino acid peptide derived from the amyloid precursor protein (APP) through sequential cleavage by β-secretase and γ-secretase. It is the most abundant form of amyloid beta in the brain and cerebrospinal fluid, constituting the majority of amyloid beta peptides produced. Aβ40 plays a role in physiological processes, including neuronal activity modulation and synaptic plasticity. However, in pathological conditions like Alzheimer’s disease, Aβ40 aggregates to form amyloid plaques, a hallmark of the disease. Compared to Aβ42, Aβ40 is less prone to aggregation, but it is still involved in early-stage plaque formation. Elevated or imbalanced Aβ40 levels are associated with vascular amyloid deposition, contributing to cerebral amyloid angiopathy and cerebrovascular dysfunction, which exacerbate cognitive decline. Monitoring Aβ40 levels in cerebrospinal fluid is often used as a biomarker in Alzheimer’s research and diagnosis.
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