Amyloid beta (1-40) Antibody
1144€ (100 µg)
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935106861
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name
Amyloid beta (1-40) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx020617
tested applications
ELISA, WB, IF/ICC
Description
Amyloid Beta (1-40) Antibody is a Mouse monoclonal antibody for neuroscience against Amyloid Beta (1-40).
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Amyloid beta (1-40) |
| Host | Mouse |
| Reactivity | Human |
| Recommended Dilution | Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Monoclonal |
| Conjugation | Unconjugated |
| Isotype | IgG1 |
| Purification | Purified from tissue culture supernatant by thiophilic adsorption and size exclusion chromatography. |
| Size 1 | 100 µg |
| Form | Lyophilized |
| Tested Applications | ELISA, WB, IF/ICC |
| Buffer | Prior to lyophilization: 2X PBS, PEG, Sucrose and 0.09% NaN3. |
| Availability | Shipped within 10-20 working days. |
| Storage | Store at -20 °C or -80 °C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| Alias | Aβ40|Amyloid Beta 40|Abeta 40|Beta-amyloid protein 40|Aβ|1-40 |
| Background | Antibody anti-Abeta40 |
| Status | RUO |
| Note | Concentration: Prior to lyophilization: 100 µg/ml - |
Descripción
Abeta40 is a 40-amino acid peptide derived from the amyloid precursor protein (APP) through sequential cleavage by β-secretase and γ-secretase. It is the most abundant form of amyloid beta in the brain and cerebrospinal fluid, constituting the majority of amyloid beta peptides produced. Aβ40 plays a role in physiological processes, including neuronal activity modulation and synaptic plasticity. However, in pathological conditions like Alzheimer’s disease, Aβ40 aggregates to form amyloid plaques, a hallmark of the disease. Compared to Aβ42, Aβ40 is less prone to aggregation, but it is still involved in early-stage plaque formation. Elevated or imbalanced Aβ40 levels are associated with vascular amyloid deposition, contributing to cerebral amyloid angiopathy and cerebrovascular dysfunction, which exacerbate cognitive decline. Monitoring Aβ40 levels in cerebrospinal fluid is often used as a biomarker in Alzheimer’s research and diagnosis.
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