Human Amyloid beta 40 (Abeta40) ELISA Kit
585€ (96 tests)
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name
Human Amyloid beta 40 (Abeta40) ELISA Kit
category
ELISA Kits
provider
Abbexa
reference
abx053393
tested applications
ELISA
Description
Human Amyloid beta 40 (Abeta40) ELISA Kit is an ELISA Kit for the in vitro quantitative measurement of Human Amyloid beta 40 (Abeta40) concentrations in serum, plasma, tissue homogenates, cell lysates and other biological fluids.
Documents del producto
Product specifications
| Category | ELISA Kits |
| Immunogen Target | Amyloid beta 40 (Abeta40) Immunogen: 672-711 AA. |
| Reactivity | Human |
| Detection Method | Colorimetric |
| Assay Data | Quantitative |
| Assay Type | Sandwich |
| Test Range | 15.6 pg/ml - 1000 pg/ml |
| Sensitivity | 9.38 pg/ml |
| Recommended Dilution | Optimal dilutions/concentrations should be determined by the end user. |
| Size 1 | 96 tests |
| Size 2 | 5 × 96 tests |
| Size 3 | 10 × 96 tests |
| Form | Standard Form: Lyophilized |
| Tested Applications | ELISA |
| Sample Type | Serum, plasma, tissue homogenates, cell lysates and other biological fluids. |
| Availability | Shipped within 5-7 working days. |
| Storage | Shipped at 4°C. Upon receipt, store the kit according to the storage instruction in the kit's manual. |
| Dry Ice | No |
| UniProt ID | P05067 |
| Alias | Aβ40|Amyloid Beta 40|Abeta 40|Beta-amyloid protein 40|Aβ|1-40 |
| Background | Elisa Kits for: Abeta40 |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES. The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments. Please note that our kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein. The stability of the kit is determined by the rate of activity loss. The loss rate is less than 5% within the expiration date under appropriate storage conditions. To minimize performance fluctuations, operation procedures and lab conditions should be strictly controlled. It is also strongly suggested that the whole assay is performed by the same user throughout. |
Descripción
Abeta40 is a 40-amino acid peptide derived from the amyloid precursor protein (APP) through sequential cleavage by β-secretase and γ-secretase. It is the most abundant form of amyloid beta in the brain and cerebrospinal fluid, constituting the majority of amyloid beta peptides produced. Aβ40 plays a role in physiological processes, including neuronal activity modulation and synaptic plasticity. However, in pathological conditions like Alzheimer’s disease, Aβ40 aggregates to form amyloid plaques, a hallmark of the disease. Compared to Aβ42, Aβ40 is less prone to aggregation, but it is still involved in early-stage plaque formation. Elevated or imbalanced Aβ40 levels are associated with vascular amyloid deposition, contributing to cerebral amyloid angiopathy and cerebrovascular dysfunction, which exacerbate cognitive decline. Monitoring Aβ40 levels in cerebrospinal fluid is often used as a biomarker in Alzheimer’s research and diagnosis.
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