Mouse Amphiphysin (AMPH) Protein
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935106861
info@markelab.com
Precio
221€ (10 µg)
Protein AMPH
proveedor
Abbexareference
abx168838Tested Applications
WB, SDS-PAGEreactivity
status
RUOclonality
Descripción
Mouse AMPH Protein is a recombinant Mouse protein produced in a Prokaryotic expression system (E. coli).
Background
AMPH or Amphiphysin, is a protein that plays important roles in the nervous system, particularly in synaptic vesicle endocytosis and membrane trafficking. Amphiphysin is a cytosolic protein found in nerve terminals, especially in the brain. It belongs to a family of proteins that contain an N-terminal BAR (Bin-Amphiphysin-Rvs) domain, a central coiled-coil domain, and a C-terminal SH3 (Src homology 3) domain. One of the main functions of Amphiphysin is its involvement in synaptic vesicle endocytosis, a process crucial for maintaining neurotransmission at synapses. It helps in the formation of clathrin-coated vesicles, which are responsible for internalizing neurotransmitter-containing vesicles after they have released their contents into the synaptic cleft.The BAR domain of Amphiphysin allows it to sense and induce membrane curvature. This ability is important for its role in shaping membranes during vesicle formation and trafficking. Amphiphysin interacts with dynamin, another protein involved in vesicle formation and fission. This interaction is crucial for the scission of clathrin-coated vesicles from the plasma membrane during endocytosis
Características del producto
category
Proteins and Peptides
origin
Mouse
host
E. coli
immunogen target
Amphiphysin (AMPH)
host
E. coli
conjugation
Unconjugated
form
Lyophilized To keep the original salt concentration, we recommend reconstituting to the original concentration prior to lyophilization (see Concentration) in ddH2O. If a lower concentration is required, dilute in PBS, pH 7.4. If a higher concentration is required, the product can be reconstituted directly in PBS, pH 7.4, though please note that this will change the overall salt concentration. The stock concentration should be between 0.1-1.0 mg/ml. Do not vortex.
tested applications
WB, SDS-PAGE
size 1
10 µg
size 2
50 µg
size 3
100 µg
size 4
200 µg
size 5
500 µg
observerd MW
Molecular Weight: Calculated MW: 29.1 kDa Concentration: Prior to lyophilization: 200 µg/ml Sequence Fragment: Val24-Asp240 Tag: N-terminal His tag
expression
Recombinant
purity
> 95%
buffer
Prior to lyophilization: PBS, pH 7.4, containing 0.01% Sarcosyl, 1 mM DTT, 5% Trehalose and Proclin-300.
storage
Store at 2-8 °C for up to one month. Store at -80 °C for up to one year. Avoid repeated freeze/thaw cycles.
or code
AMPH
dry ice
No
availability
Shipped within 5-7 working days.
alias
AMPH,AMPH1
uniprot id
note
This product is for research use only. Not for human consumption, cosmetic, therapeutic or diagnostic use.
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