Mouse Amphiphysin (AMPH) ELISA Kit

Product specifications

ELISA Kits

Amphiphysin (AMPH)

Mouse

Colorimetric

Quantitative

0.156 ng/ml - 10 ng/ml

Optimal dilutions/concentrations should be determined by the end user.

96 tests

Lyophilized

ELISA

Tissue homogenates, cell lysates and other biological fluids.

Shipped within 5-15 working days. The validity for this kit is 6 months.

Shipped at 4 °C. Upon receipt, store the kit according to the storage instruction in the kit's manual.

No

Q7TQF7

218038

AMPH,AMPH1

Elisa kits for AMPH

RUO

Validity: The validity for this kit is 6 months.

This product is for research use only.   The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments.   Please note that our ELISA and CLIA kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein.

Descripción

AMPH or Amphiphysin, is a protein that plays important roles in the nervous system, particularly in synaptic vesicle endocytosis and membrane trafficking. Amphiphysin is a cytosolic protein found in nerve terminals, especially in the brain. It belongs to a family of proteins that contain an N-terminal BAR (Bin-Amphiphysin-Rvs) domain, a central coiled-coil domain, and a C-terminal SH3 (Src homology 3) domain. One of the main functions of Amphiphysin is its involvement in synaptic vesicle endocytosis, a process crucial for maintaining neurotransmission at synapses. It helps in the formation of clathrin-coated vesicles, which are responsible for internalizing neurotransmitter-containing vesicles after they have released their contents into the synaptic cleft.The BAR domain of Amphiphysin allows it to sense and induce membrane curvature. This ability is important for its role in shaping membranes during vesicle formation and trafficking. Amphiphysin interacts with dynamin, another protein involved in vesicle formation and fission. This interaction is crucial for the scission of clathrin-coated vesicles from the plasma membrane during endocytosis

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Amphiphysin(AMPH), a synaptic vesicle-associated protein that is highly concentrated in nerve terminal, is an autoantigen of Stiff-Man syndrome with breast cancer. Amphiphysin contains a N-terminal BAR(Bin1/Amphiphysin/Rv167) domain followed by an endocytosis domain, and a C-terminal SH3 domain. Amphiphysin has been proposed to function as a linker between the clathrin coat and dynamin in the endocytosis of synaptic vesicles. It may also participate in mechanisms of regulated exocytosis in synapses and certain endocrine cell types.

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