Mouse Alpha Actinin 4 (ACTN4) ELISA Kit
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Pida mas información
935106861
info@markelab.com
Precio
715€ (96 tests)
Elisa kits for ACTN4
proveedor
Abbexareference
abx517032Tested Applications
ELISAreactivity
Mousestatus
RUOclonality
Descripción
Mouse Alpha Actinin 4 (ACTN4) ELISA Kit is an ELISA Kit for the in vitro quantitative measurement of Mouse Alpha Actinin 4 (ACTN4) concentrations in tissue homogenates, cell lysates and other biological fluids.
Background
ACTN4 encodes alpha-actinin-4, a non-muscle isoform of the actinin family that plays a critical role in cellular motility, adhesion, and signal transduction. It is widely expressed in various tissues, where it crosslinks actin filaments and interacts with focal adhesion proteins to regulate cytoskeletal organization and mechanotransduction. ACTN4 is particularly important in podocytes of the kidney, where it contributes to the maintenance of glomerular filtration barrier integrity. Mutations in ACTN4 are associated with focal segmental glomerulosclerosis (FSGS), a kidney disease characterized by proteinuria and progressive renal failure. In addition to its structural role, ACTN4 is implicated in cancer metastasis and cell invasion, reflecting its involvement in dynamic cellular processes. Its diverse functions in cytoskeletal dynamics and signal regulation highlight its importance in cellular stability and adaptability.
Características del producto
category
ELISA Kits
immunogen target
Alpha Actinin 4 (ACTN4)
reactivity
Mouse
test range
78 pg/ml - 5000 pg/ml
assay type
Sandwich
assay data
Quantitative
form
Lyophilized
detection method
Colorimetric
sample type
Tissue homogenates, cell lysates and other biological fluids.
size 1
96 tests
alias
ACTN4,ACTININ-4,FSGS,FSGS1
storage
Shipped at 4 °C. Upon receipt, store the kit according to the storage instruction in the kit's manual.
or code
ACTN4
dry ice
No
uniprot id
note
This product is for research use only. The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments. Please note that our ELISA and CLIA kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein.
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