Alpha Actinin 4 (ACTN4) Antibody
357.5€ (100 µg)
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Name
Alpha Actinin 4 (ACTN4) Antibody
Category
Primary Antibodies
Provider
Abbexa
Reference
abx036204
Tested Applications
ELISA, WB, IHC
Description
Rabbit Polyclonal against the ACTN4 protein.
Documentos del producto
Instrucciones
Data sheet
Especificaciones del producto
| Category | Primary Antibodies |
| Immunogen Target | Target: Alpha Actinin 4 (ACTN4) Immunogen: Recombinant fragment corresponding to 397-648 AA of human ACTN4. |
| Host | Rabbit |
| Reactivity | Human |
| Assay Type | Concentration: Lyophilized form: Not applicable. After reconstitution: 1 mg/ml. |
| Recommended Dilution | ELISA: 1/20000 - 1/80000, WB: 1/500 - 1/2000, IHC: 1/100 - 1/200. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Observed MW | Observed MW: 60 kDa |
| Purification | Purified by antigen affinity column chromatography. |
| Size 1 | 100 µg |
| Size 2 | 1 mg |
| Form | Lyophilized |
| Tested Applications | ELISA, WB, IHC |
| Buffer | Prior to lyophilization: 1% BSA and 0.02% NaN3. |
| Availability | Shipped within 7-15 working days. |
| Storage | Store at -20 °C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| Alias | ACTN4,ACTININ-4,FSGS,FSGS1 |
| Background | Antibody anti-ACTN4 |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |
Background
ACTN4 encodes alpha-actinin-4, a non-muscle isoform of the actinin family that plays a critical role in cellular motility, adhesion, and signal transduction. It is widely expressed in various tissues, where it crosslinks actin filaments and interacts with focal adhesion proteins to regulate cytoskeletal organization and mechanotransduction. ACTN4 is particularly important in podocytes of the kidney, where it contributes to the maintenance of glomerular filtration barrier integrity. Mutations in ACTN4 are associated with focal segmental glomerulosclerosis (FSGS), a kidney disease characterized by proteinuria and progressive renal failure. In addition to its structural role, ACTN4 is implicated in cancer metastasis and cell invasion, reflecting its involvement in dynamic cellular processes. Its diverse functions in cytoskeletal dynamics and signal regulation highlight its importance in cellular stability and adaptability.
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