Mouse Alkylated DNA repair protein alkB homolog 8 (ALKBH8) ELISA Kit
715€ (96 tests)
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935106861
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name
Mouse Alkylated DNA repair protein alkB homolog 8 (ALKBH8) ELISA Kit
category
ELISA Kits
provider
Abbexa
reference
abx501572
tested applications
ELISA
Description
Mouse Alkylated DNA repair protein alkB homolog 8 (ALKBH8) ELISA Kit is an ELISA Kit for the in vitro quantitative measurement of Mouse Alkylated DNA repair protein alkB homolog 8 concentrations in tissue homogenates, cell lysates and other biological fluids.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | ELISA Kits |
| Immunogen Target | Alkylated DNA repair protein alkB homolog 8 (ALKBH8) |
| Reactivity | Mouse |
| Detection Method | Colorimetric |
| Assay Data | Quantitative |
| Test Range | 0.156 ng/ml - 10 ng/ml |
| Recommended Dilution | Optimal dilutions/concentrations should be determined by the end user. |
| Size 1 | 96 tests |
| Form | Lyophilized |
| Tested Applications | ELISA |
| Sample Type | Tissue homogenates, cell lysates and other biological fluids. |
| Availability | Shipped within 5-15 working days. The validity for this kit is 6 months. |
| Storage | Shipped at 4 °C. Upon receipt, store the kit according to the storage instruction in the kit's manual. |
| Dry Ice | No |
| UniProt ID | Q80Y20 |
| Gene ID | 67667 |
| Alias | ALKBH8,ABH8 |
| Background | Elisa kits for ALKBH8 |
| Status | RUO |
| Note | Validity: The validity for this kit is 6 months. This product is for research use only. The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments. Please note that our ELISA and CLIA kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein. |
Descripción
ALKBH8 is a unique member of the ALKB family that functions as a tRNA methyltransferase and oxidative repair enzyme. It catalyzes the methylation of specific nucleotides in tRNA, particularly wobble uridine residues, ensuring proper tRNA stability, codon recognition, and accurate translation. ALKBH8 also possesses RNA repair activity, where it oxidatively repairs methylated lesions in tRNA, ensuring the maintenance of functional tRNA pools. This dual function makes ALKBH8 critical for maintaining translational fidelity and cellular protein synthesis. ALKBH8 is particularly important under oxidative stress, where it repairs alkylation-induced RNA damage and prevents translational errors. Dysregulation of ALKBH8 has been linked to cancer progression, as defective tRNA modification can disrupt protein synthesis and cellular homeostasis. Its role in enhancing translational accuracy and stress adaptation highlights its importance in tumor suppression, metabolic regulation, and cellular defense mechanisms.
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