Mouse Alkylated DNA repair protein alkB homolog 8 (ALKBH8) ELISA Kit
Pida mas información
935106861
info@markelab.com
Precio
687.5€ (96 tests)
Elisa Kits ALKBH8
proveedor
Abbexareference
abx501572Tested Applications
ELISAreactivity
Mousestatus
RUOclonality
Descripción
Mouse Alkylated DNA repair protein alkB homolog 8 (ALKBH8) ELISA Kit is an ELISA Kit for the in vitro quantitative measurement of Mouse Alkylated DNA repair protein alkB homolog 8 concentrations in tissue homogenates, cell lysates and other biological fluids.
Background
ALKBH8 is a unique member of the ALKB family that functions as a tRNA methyltransferase and oxidative repair enzyme. It catalyzes the methylation of specific nucleotides in tRNA, particularly wobble uridine residues, ensuring proper tRNA stability, codon recognition, and accurate translation. ALKBH8 also possesses RNA repair activity, where it oxidatively repairs methylated lesions in tRNA, ensuring the maintenance of functional tRNA pools. This dual function makes ALKBH8 critical for maintaining translational fidelity and cellular protein synthesis. ALKBH8 is particularly important under oxidative stress, where it repairs alkylation-induced RNA damage and prevents translational errors. Dysregulation of ALKBH8 has been linked to cancer progression, as defective tRNA modification can disrupt protein synthesis and cellular homeostasis. Its role in enhancing translational accuracy and stress adaptation highlights its importance in tumor suppression, metabolic regulation, and cellular defense mechanisms.
Características del producto
category
ELISA Kits
immunogen target
Alkylated DNA repair protein alkB homolog 8 (ALKBH8)
reactivity
Mouse
test range
0.156 ng/ml - 10 ng/ml
assay data
Quantitative
detection method
Colorimetric
sample type
Tissue homogenates,Cell lysates,Other biological fluids
size 1
96 tests
alias
ALKBH8,ABH8
storage
Enviado a 4 °C. Una vez recibido, almacene el kit de acuerdo con las instrucciones citadas en el manual del kit
or code
ALKBH8
dry ice
No
uniprot id
note
This product is for research use only. <p></p> The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments. <p></p> Please note that our ELISA and CLIA kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein.
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