Alkylated DNA Repair Protein AlkB Homolog 8 (ALKBH8) Antibody

Este producto es parte de ALKBH - alkB homolog
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357.5€ (100 µg)

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935106861
info@markelab.com
name
Alkylated DNA Repair Protein AlkB Homolog 8 (ALKBH8) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx036470
tested applications
ELISA, WB, IHC

Description

Rabbit Polyclonal against the ALKBH8 protein.

Documents del producto

Instrucciones
Data sheet
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Product specifications

Category
Primary Antibodies
Immunogen Target
Alkylated DNA Repair Protein AlkB Homolog 8 (ALKBH8)
Host
Rabbit
Reactivity
Human
Recommended Dilution
ELISA: 1/20000 - 1/80000, WB: 1/500 - 1/2000, IHC: 1/100 - 1/200. Optimal dilutions/concentrations should be determined by the end user.
Clonality
Polyclonal
Conjugation
Unconjugated
Isotype
IgG
Purification
Purified by antigen affinity column chromatography.
Size 1
100 µg
Size 2
1 mg
Form
Lyophilized
Tested Applications
ELISA, WB, IHC
Buffer
Prior to lyophilization: 1% BSA and 0.02% NaN3.
Availability
Shipped within 7-15 working days.
Storage
Store at -20 °C. Avoid repeated freeze/thaw cycles.
Dry Ice
No
Alias
ALKBH8,ABH8
Background
Antibody anti-ALKBH8
Status
RUO
Note
Concentration: Lyophilized form: Not applicable.  After reconstitution: 1 mg/ml. -

Descripción

ALKBH8 is a unique member of the ALKB family that functions as a tRNA methyltransferase and oxidative repair enzyme. It catalyzes the methylation of specific nucleotides in tRNA, particularly wobble uridine residues, ensuring proper tRNA stability, codon recognition, and accurate translation. ALKBH8 also possesses RNA repair activity, where it oxidatively repairs methylated lesions in tRNA, ensuring the maintenance of functional tRNA pools. This dual function makes ALKBH8 critical for maintaining translational fidelity and cellular protein synthesis. ALKBH8 is particularly important under oxidative stress, where it repairs alkylation-induced RNA damage and prevents translational errors. Dysregulation of ALKBH8 has been linked to cancer progression, as defective tRNA modification can disrupt protein synthesis and cellular homeostasis. Its role in enhancing translational accuracy and stress adaptation highlights its importance in tumor suppression, metabolic regulation, and cellular defense mechanisms.

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