Alkylated DNA Repair Protein AlkB Homolog 8 (ALKBH8) Antibody
195€ (20 µl)
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935106861
info@markelab.com
name
Alkylated DNA Repair Protein AlkB Homolog 8 (ALKBH8) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx005393
tested applications
ELISA, WB, IHC
Description
ALKBH8 Antibody is a Rabbit Polyclonal antibody against ALKBH8.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Alkylated DNA Repair Protein AlkB Homolog 8 (ALKBH8) |
| Host | Rabbit |
| Reactivity | Human, Mouse, Rat |
| Recommended Dilution | ELISA: 1 µg/ml, WB: 1/2000 - 1/10000, IHC-P: 1/100 - 1/200. Not tested in IHC-F. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Purified by affinity chromatography. |
| Size 1 | 20 µl |
| Size 2 | 100 µl |
| Size 3 | 2 × 100 µl |
| Form | Liquid |
| Tested Applications | ELISA, WB, IHC |
| Buffer | PBS, pH 7.3, containing 0.02% sodium azide, 50% glycerol. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | Q96BT7 |
| Gene ID | 91801 |
| NCBI Accession | NP_620130.2 |
| Alias | ALKBH8,ABH8 |
| Background | Antibody anti-ALKBH8 |
| Status | RUO |
| Note | Concentration: 1.15 mg/ml - |
Descripción
ALKBH8 is a unique member of the ALKB family that functions as a tRNA methyltransferase and oxidative repair enzyme. It catalyzes the methylation of specific nucleotides in tRNA, particularly wobble uridine residues, ensuring proper tRNA stability, codon recognition, and accurate translation. ALKBH8 also possesses RNA repair activity, where it oxidatively repairs methylated lesions in tRNA, ensuring the maintenance of functional tRNA pools. This dual function makes ALKBH8 critical for maintaining translational fidelity and cellular protein synthesis. ALKBH8 is particularly important under oxidative stress, where it repairs alkylation-induced RNA damage and prevents translational errors. Dysregulation of ALKBH8 has been linked to cancer progression, as defective tRNA modification can disrupt protein synthesis and cellular homeostasis. Its role in enhancing translational accuracy and stress adaptation highlights its importance in tumor suppression, metabolic regulation, and cellular defense mechanisms.
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