Mouse Aldoc(Fructose-bisphosphate aldolase C) ELISA Kit

Este producto es parte de ALDOC - Fructose-Bisphosphate Aldolase C
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935106861
info@markelab.com
name
Mouse Aldoc(Fructose-bisphosphate aldolase C) ELISA Kit
category
ELISA Kits
provider
FineTest
reference
EM6121

Documents del producto

Instrucciones
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Data sheet

Product specifications

CategoryELISA Kits
Reactivitymouse
Detection MethodColorimetric
Assay DataQuantitative
Assay TypeSandwich ELISA, Double Antibody
Test Range78.125-5000pg/ml
Size 196T
Sample TypeBusacar en las instrucciones
AvailabilityShipped within 10-14 working days.
Storage2-8 °C for 6 months
UniProt IDP05063
AliasALDOC,ALDC
BackgroundElisa Kits ALDOC
StatusRUO

ALDOC is a brain-specific isoform of fructose-bisphosphate aldolase that catalyzes the same glycolytic reaction as ALDOA and ALDOB, converting fructose-1,6-bisphosphate into glyceraldehyde-3-phosphate and dihydroxyacetone phosphate. ALDOC is highly expressed in the central nervous system (CNS), particularly in astrocytes and Purkinje cells of the cerebellum, where it plays a key role in brain energy metabolism and glucose utilization. Altered expression or mutations in ALDOC are linked to neurodegenerative disorders and gliomas, where energy metabolism is disrupted. Additionally, ALDOC is involved in maintaining neuronal function and astrocyte homeostasis under normal and stress conditions. Its critical role in glycolysis makes it essential for supporting brain function and energy demands.

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Fructose-bisphosphate aldolase C(ALDOC) reversibly cleaves FBP and F1-P to glyceraldehyde 3-phosphate and dihydroxyacetone phosphate and is strongly expressed in mammalian brain together with ALDOA and is alsopresent in the heart and spleen of some species(PMID:9363598). It is involed in glycolysis as an important enzyme. Phospholipase D2 and inositol 1,4,5-triphosphate interact with ALDOC in signal transduction. Meanwhile, the protein expression of ALDOC has been reported to be regulated in brain tumor, hepatomas, and lung cancer(PMID:21548097).

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