Mouse Abhydrolase domain-containing protein 2 (ABHD2) ELISA Kit
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Description
Mouse Abhydrolase domain-containing protein 2 (ABHD2) ELISA Kit is an ELISA Kit for the in vitro quantitative measurement of Mouse Abhydrolase domain-containing protein 2 concentrations in tissue homogenates, cell lysates and other biological fluids.
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Product specifications
| Category | ELISA Kits |
| Immunogen Target | Abhydrolase domain-containing protein 2 (ABHD2) |
| Reactivity | Mouse |
| Detection Method | Colorimetric |
| Assay Data | Quantitative |
| Test Range | 0.156 ng/ml - 10 ng/ml |
| Recommended Dilution | Optimal dilutions/concentrations should be determined by the end user. |
| Size 1 | 96 tests |
| Form | Lyophilized |
| Tested Applications | ELISA |
| Sample Type | Tissue homogenates, cell lysates and other biological fluids. |
| Availability | Shipped within 5-15 working days. The validity for this kit is 6 months. |
| Storage | Shipped at 4 °C. Upon receipt, store the kit according to the storage instruction in the kit's manual. |
| Dry Ice | No |
| UniProt ID | Q9QXM0 |
| Gene ID | 54608 |
| Alias | HS1-2,LABH2,PHPS1-2 |
| Background | Elisa kits for ABHD2 |
| Status | RUO |
| Note | Validity: The validity for this kit is 6 months. This product is for research use only. The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments. Please note that our ELISA and CLIA kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein. |
Descripción
ABHD2 is a serine hydrolase well-known for its role in sperm activation and fertilization by regulating the CatSper calcium channel, which is activated by progesterone. This calcium influx is essential for sperm motility and the acrosome reaction. Beyond reproduction, ABHD2 is expressed in the lungs, brain, and immune cells, where it hydrolyzes bioactive lipids, including 2-arachidonoylglycerol (2-AG), a key endocannabinoid. Through lipid metabolism, ABHD2 modulates inflammatory responses, immune signaling, and cellular lipid composition. Dysregulation of ABHD2 has been associated with infertility, due to impaired sperm activation, and inflammatory diseases, highlighting its dual importance in reproductive biology and immune regulation. Structurally, ABHD2 features a catalytic triad within its hydrolase domain, driving its activity in lipid processing and signaling. Its multifunctionality and therapeutic relevance make it a critical target for understanding lipid metabolism in both reproductive and systemic contexts.
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