Abhydrolase Domain Containing 2 (ABHD2) Antibody
357.5€ (100 µg)
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Name
Abhydrolase Domain Containing 2 (ABHD2) Antibody
Category
Primary Antibodies
Provider
Abbexa
Reference
abx036554
Tested Applications
ELISA, WB
Description
Rabbit Polyclonal against the ABHD2 protein.
Documentos del producto
Instrucciones
Data sheet
Especificaciones del producto
| Category | Primary Antibodies |
| Immunogen Target | Target: Abhydrolase Domain Containing 2 (ABHD2) Immunogen: Recombinant fragment corresponding to 81-384 AA of human ABHD2. |
| Host | Rabbit |
| Reactivity | Human |
| Assay Type | Concentration: Lyophilized form: Not applicable. After reconstitution: 1 mg/ml. |
| Recommended Dilution | ELISA: 1/20000 - 1/80000, WB: 1/500 - 1/2000. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Observed MW | Observed MW: 48 kDa |
| Purification | Purified by antigen affinity column chromatography. |
| Size 1 | 100 µg |
| Size 2 | 1 mg |
| Form | Lyophilized |
| Tested Applications | ELISA, WB |
| Buffer | Prior to lyophilization: 1% BSA and 0.02% NaN3. |
| Availability | Shipped within 7-15 working days. |
| Storage | Store at -20 °C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| Alias | HS1-2,LABH2,PHPS1-2 |
| Background | Antibody anti-ABHD2 |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |
Background
ABHD2 is a serine hydrolase well-known for its role in sperm activation and fertilization by regulating the CatSper calcium channel, which is activated by progesterone. This calcium influx is essential for sperm motility and the acrosome reaction. Beyond reproduction, ABHD2 is expressed in the lungs, brain, and immune cells, where it hydrolyzes bioactive lipids, including 2-arachidonoylglycerol (2-AG), a key endocannabinoid. Through lipid metabolism, ABHD2 modulates inflammatory responses, immune signaling, and cellular lipid composition. Dysregulation of ABHD2 has been associated with infertility, due to impaired sperm activation, and inflammatory diseases, highlighting its dual importance in reproductive biology and immune regulation. Structurally, ABHD2 features a catalytic triad within its hydrolase domain, driving its activity in lipid processing and signaling. Its multifunctionality and therapeutic relevance make it a critical target for understanding lipid metabolism in both reproductive and systemic contexts.
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