Mouse Abelson Tyrosine-Protein Kinase 2 (ABL2) ELISA Kit

Este producto es parte de ABL - Tyrosine-protein kinase ABL
Mouse Abelson Tyrosine-Protein Kinase 2 (ABL2) ELISA Kit
715€ (96 tests)

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Name
Mouse Abelson Tyrosine-Protein Kinase 2 (ABL2) ELISA Kit
Category
ELISA Kits
Provider
Abbexa
Reference
abx392269
Tested Applications
ELISA

Description

Mouse Abelson Tyrosine-Protein Kinase 2 (ABL2) ELISA Kit is an ELISA Kit for the in vitro quantitative measurement of Mouse Abelson tyrosine-protein kinase 2 (Abl2) concentrations in tissue homogenates, cell lysates and other biological fluids.

Documentos del producto

Instrucciones
Data sheet
Descargar

Especificaciones del producto

Category
ELISA Kits
Immunogen Target
Abelson Tyrosine-Protein Kinase 2 (ABL2)
Reactivity
Mouse
Detection Method
Colorimetric
Assay Data
Quantitative
Assay Type
Sandwich
Test Range
78 pg/ml - 5000 pg/ml
Sensitivity
< 46.9 pg/ml
Recommended Dilution
Optimal dilutions/concentrations should be determined by the end user.
Size 1
96 tests
Form
Standard Form: Lyophilized
Tested Applications
ELISA
Sample Type
Tissue homogenates, cell lysates and other biological fluids.
Availability
Shipped within 5-12 working days.
Storage
Shipped at 4 °C. Upon receipt, store the kit according to the storage instruction in the kit's manual.
Dry Ice
No
UniProt ID
Q4JIM5
Alias
ABLL,ARG,ABL proto-oncogene 2 non-receptor tyrosine kinase,Abelson Tyrosine Protein Kinase 2
Background
Elisa Kits for: ABL2
Status
RUO
Note
THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES. The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments. Please note that our kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein.
The stability of the kit is determined by the rate of activity loss. The loss rate is less than 5% within the expiration date under appropriate storage conditions. To minimize performance fluctuations, operation procedures and lab conditions should be strictly controlled. It is also strongly suggested that the whole assay is performed by the same user throughout.

Background

ABL2, also known as ARG (ABL-related gene), is a non-receptor tyrosine kinase closely related to ABL1, with overlapping roles in regulating actin cytoskeleton remodeling, cell adhesion, and migration. ABL2 is localized predominantly in the cytoplasm and membrane structures, where it interacts with actin-binding proteins and cytoskeletal components to regulate cell shape and motility. It contains similar structural domains to ABL1, including SH2 and SH3 domains, a kinase domain, and actin-binding regions that enable its role in cytoskeletal organization and intracellular signaling. ABL2 is highly expressed in tissues involved in structural integrity and movement, such as neurons and fibroblasts. Dysregulation of ABL2 activity has been implicated in cancer metastasis and neuronal disorders, where altered cell motility and adhesion contribute to disease progression. ABL2's role in neuronal development and its involvement in cancer highlight its potential as a therapeutic target in both neurodegenerative diseases and oncology.

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