Abelson Tyrosine-Protein Kinase 2 (ABL2) Antibody

Este producto es parte de ABL - Tyrosine-protein kinase ABL
Abelson Tyrosine-Protein Kinase 2 (ABL2) Antibody

Pida mas información

935106861

info@markelab.com

Precio

383.5€ (100 µl)

Antibody anti-ABL2

proveedor

Abbexa

reference

abx010343

Tested Applications

ELISA, IF/ICC

reactivity

Human

status

RUO

clonality

Monoclonal

Descripción

ABL2 is a cytoplasmic tyrosine kinase which is closely related to but distinct from ABL1. The similarity of the proteins includes the tyrosine kinase domains and extends amino-terminal to include the SH2 and SH3 domains. ABL2 is expressed in both normal and tumor cells. The ABL2 gene product is expressed as two variants bearing different amino termini, both approximately 12-kb in length.


Background

ABL2, also known as ARG (ABL-related gene), is a non-receptor tyrosine kinase closely related to ABL1, with overlapping roles in regulating actin cytoskeleton remodeling, cell adhesion, and migration. ABL2 is localized predominantly in the cytoplasm and membrane structures, where it interacts with actin-binding proteins and cytoskeletal components to regulate cell shape and motility. It contains similar structural domains to ABL1, including SH2 and SH3 domains, a kinase domain, and actin-binding regions that enable its role in cytoskeletal organization and intracellular signaling. ABL2 is highly expressed in tissues involved in structural integrity and movement, such as neurons and fibroblasts. Dysregulation of ABL2 activity has been implicated in cancer metastasis and neuronal disorders, where altered cell motility and adhesion contribute to disease progression. ABL2's role in neuronal development and its involvement in cancer highlight its potential as a therapeutic target in both neurodegenerative diseases and oncology.

Características del producto

category

Primary Antibodies


clonality

Monoclonal


reactivity

Human


immunogen target

Abelson Tyrosine-Protein Kinase 2 (ABL2)


host

Mouse


isotype

IgG1


conjugation

Unconjugated


form

Liquid


tested applications

ELISA, IF/ICC


purification

Unpurified ascites.


recommended dilution

ELISA: 1/10000, IF/ICC: 1/200 - 1/1000. Optimal dilutions/concentrations should be determined by the end user.


buffer

Ascitic fluid containing 0.03% sodium azide.


size 1

100 µl


storage

Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.


or code

ABL2


dry ice

No


availability

Shipped within 5-10 working days.


alias

ABLL,ARG,ABL proto-oncogene 2 non-receptor tyrosine kinase,Abelson Tyrosine Protein Kinase 2


note

Concentration: Not determined. -


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status

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