Abelson Tyrosine-Protein Kinase 2 (ABL2) Antibody
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Pida mas información
935106861
info@markelab.com
Precio
383.5€ (100 µl)
Antibody anti-ABL2
proveedor
Abbexareference
abx010343Tested Applications
ELISA, IF/ICCreactivity
Humanstatus
RUOclonality
MonoclonalDescripción
ABL2 is a cytoplasmic tyrosine kinase which is closely related to but distinct from ABL1. The similarity of the proteins includes the tyrosine kinase domains and extends amino-terminal to include the SH2 and SH3 domains. ABL2 is expressed in both normal and tumor cells. The ABL2 gene product is expressed as two variants bearing different amino termini, both approximately 12-kb in length.
Background
ABL2, also known as ARG (ABL-related gene), is a non-receptor tyrosine kinase closely related to ABL1, with overlapping roles in regulating actin cytoskeleton remodeling, cell adhesion, and migration. ABL2 is localized predominantly in the cytoplasm and membrane structures, where it interacts with actin-binding proteins and cytoskeletal components to regulate cell shape and motility. It contains similar structural domains to ABL1, including SH2 and SH3 domains, a kinase domain, and actin-binding regions that enable its role in cytoskeletal organization and intracellular signaling. ABL2 is highly expressed in tissues involved in structural integrity and movement, such as neurons and fibroblasts. Dysregulation of ABL2 activity has been implicated in cancer metastasis and neuronal disorders, where altered cell motility and adhesion contribute to disease progression. ABL2's role in neuronal development and its involvement in cancer highlight its potential as a therapeutic target in both neurodegenerative diseases and oncology.
Características del producto
category
Primary Antibodies
clonality
Monoclonal
reactivity
Human
immunogen target
Abelson Tyrosine-Protein Kinase 2 (ABL2)
host
Mouse
isotype
IgG1
conjugation
Unconjugated
form
Liquid
tested applications
ELISA, IF/ICC
purification
Unpurified ascites.
recommended dilution
ELISA: 1/10000, IF/ICC: 1/200 - 1/1000. Optimal dilutions/concentrations should be determined by the end user.
buffer
Ascitic fluid containing 0.03% sodium azide.
size 1
100 µl
storage
Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
or code
ABL2
dry ice
No
availability
Shipped within 5-10 working days.
alias
ABLL,ARG,ABL proto-oncogene 2 non-receptor tyrosine kinase,Abelson Tyrosine Protein Kinase 2
uniprot id
note
Concentration: Not determined. -
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proveedor
FineTestreference
FNab00053Tested Applications
ELISA, WB, IF, IHC, IPreactivity
human,mouse,ratstatus
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
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Abbexareference
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ELISA, IF/ICCreactivity
Humanstatus
RUOclonality
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
proveedor
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ELISA, IF/ICCreactivity
Human, Mousestatus
RUOclonality
MonoclonalABL2 (ARG, Abl-related gene), together with c-Abl, forms the Abl family of mammalian non-receptor tyrosine kinases.ABL2 ...
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