Abelson Tyrosine-Protein Kinase 2 (ABL2) Antibody
383.5€ (100 µl)
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Name
Abelson Tyrosine-Protein Kinase 2 (ABL2) Antibody
Category
Primary Antibodies
Provider
Abbexa
Reference
abx015718
Tested Applications
ELISA, IF/ICC
Description
ABL2 (ARG, Abl-related gene), together with c-Abl, forms the Abl family of mammalian non-receptor tyrosine kinases.ABL2 and c-Abl share 89%, 90 and 93% identity in their SH3, SH2 and tyrosine domain, but only 29% identity in the carboxy-terminal half.The human c-Abl and ABL2 genes are expressed ubiquitously.ABL2 had been detected predominantly in the cytoplasm, whereas c-Abl shows both cytoplasmic and nuclear localization.c-Abl is involved in two different chromosomal translocations present in human leukemias, which generate Bcr-Abl and TEL-Abl.Recently, TEL-ARG fusion transcripts have also been identified in acute myeloid leukemias (AML).The Abl family kinases may also interact with receptor tyrosine signaling pathways and regulate cellular function such as cell cycle progression, gene transcription and organization of the actin cytoskeletons in neurons.
Documentos del producto
Instrucciones
Data sheet
Especificaciones del producto
| Category | Primary Antibodies |
| Immunogen Target | Target: Abelson Tyrosine-Protein Kinase 2 (ABL2) Immunogen: Purified recombinant fragment of ABL2 expressed in E. coli. |
| Host | Mouse |
| Reactivity | Human, Mouse |
| Assay Type | Concentration: Not determined. |
| Recommended Dilution | ELISA: 1/10000, IF/ICC: 1/200 - 1/1000. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Monoclonal |
| Conjugation | Unconjugated |
| Isotype | IgG1 |
| Observed MW | 128 kDa |
| Purification | Unpurified ascites. |
| Size 1 | 100 µl |
| Form | Liquid |
| Tested Applications | ELISA, IF/ICC |
| Buffer | Ascitic fluid containing 0.03% sodium azide. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | P42684 |
| Gene ID | 27 |
| Alias | ABLL,ARG,ABL proto-oncogene 2 non-receptor tyrosine kinase,Abelson Tyrosine Protein Kinase 2 |
| Background | Antibody anti-ABL2 |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |
Background
ABL2, also known as ARG (ABL-related gene), is a non-receptor tyrosine kinase closely related to ABL1, with overlapping roles in regulating actin cytoskeleton remodeling, cell adhesion, and migration. ABL2 is localized predominantly in the cytoplasm and membrane structures, where it interacts with actin-binding proteins and cytoskeletal components to regulate cell shape and motility. It contains similar structural domains to ABL1, including SH2 and SH3 domains, a kinase domain, and actin-binding regions that enable its role in cytoskeletal organization and intracellular signaling. ABL2 is highly expressed in tissues involved in structural integrity and movement, such as neurons and fibroblasts. Dysregulation of ABL2 activity has been implicated in cancer metastasis and neuronal disorders, where altered cell motility and adhesion contribute to disease progression. ABL2's role in neuronal development and its involvement in cancer highlight its potential as a therapeutic target in both neurodegenerative diseases and oncology.
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