Mouse A-Kinase Anchor Protein 8 Like (AKAP8L) ELISA Kit
Por favor contáctenos para obtener información detallada sobre el precio y disponibilidad.
Description
Mouse A-Kinase Anchor Protein 8 Like (AKAP8L) ELISA Kit is an ELISA Kit for the in vitro quantitative measurement of Mouse A-Kinase Anchor Protein 8 Like (AKAP8L) concentrations in tissue homogenates, cell lysates and other biological fluids.
Documents del producto
Product specifications
| Category | ELISA Kits |
| Immunogen Target | A-Kinase Anchor Protein 8 Like (AKAP8L) |
| Reactivity | Mouse |
| Detection Method | Colorimetric |
| Assay Data | Quantitative |
| Assay Type | Sandwich |
| Test Range | 78 pg/ml - 5000 pg/ml |
| Sensitivity | < 46.9 pg/ml |
| Recommended Dilution | Optimal dilutions/concentrations should be determined by the end user. |
| Size 1 | 96 tests |
| Form | Lyophilized |
| Tested Applications | ELISA |
| Sample Type | Tissue homogenates, cell lysates and other biological fluids. |
| Availability | Shipped within 5-12 working days. The validity for this kit is 6 months. |
| Storage | Shipped at 4 °C. Upon receipt, store the kit according to the storage instruction in the kit's manual. |
| Dry Ice | No |
| UniProt ID | Q9R0L7 |
| Alias | NAKAP, NAKAP95 |
| Background | Elisa kits for AKAP8L |
| Status | RUO |
| Note | Validity: The validity for this kit is 6 months. This product is for research use only. The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments. Please note that our ELISA and CLIA kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein. |
Descripción
A Kinase Anchor Protein 8-Like (AKAP8L) is a member of the AKAP family of scaffolding proteins that anchor protein kinase A (PKA) and other signaling molecules to specific subcellular locations, thereby compartmentalizing signaling pathways. AKAP8L is predominantly localized in the nucleus, where it plays a critical role in RNA processing, chromatin remodeling, and transcriptional regulation. It is involved in coordinating events such as mRNA splicing and nuclear export, and it may also contribute to mitotic progression through its interactions with chromatin-associated proteins. AKAP8L facilitates the integration of signaling cascades with gene expression, highlighting its role in cellular adaptation to external and internal cues. Dysregulation of AKAP8L has been implicated in cancer and other diseases, where disrupted nuclear signaling and chromatin dynamics affect cell proliferation and survival. Emerging research suggests AKAP8L’s involvement in stress responses, particularly in modulating nuclear processes under conditions of DNA damage or oxidative stress, making it a potential target for therapeutic intervention.
Related Products
AKAP8L antibody
Could play a role in constitutive transport element(CTE)-mediated gene expression by association with DHX9. Increases CTE-dependent nuclear unspliced mRNA export(PubMed:10748171, PubMed:11402034). Proposed to target PRKACA to the nucleus but does not seem to be implicated in the binding of regulatory subunit II of PKA(PubMed:10761695, PubMed:11884601). May be involved in nuclear envelope breakdown and chromatin condensation. May be involved in anchoring nuclear membranes to chromatin in interphase and in releasing membranes from chromating at mitosis(PubMed:11034899). May regulate the initiation phase of DNA replication when associated with TMPO isoform Beta(PubMed:12538639). Required for cell cycle G2/M transition and histone deacetylation during mitosis. In mitotic cells recruits HDAC3 to the vicinity of chromatin leading to deacetylation and subsequent phosphorylation at 'Ser-10' of histone H3; in this function seems to act redundantly with AKAP8(PubMed:16980585). May be involved in regulation of pre-mRNA splicing(PubMed:17594903). (Microbial infection) In case of EBV infection, may target PRKACA to EBNA-LP-containing nuclear sites to modulate transcription from specific promoters(PubMed:11884601). Can synergize with DHX9 to activate the CTE-mediated gene expression of type D retroviruses(PubMed:11402034). In case of HIV-1 infection, involved in the DHX9-promoted annealing of host tRNA(Lys3) to viral genomic RNA as a primer in reverse transcription; in vitro negatively regulates DHX9 annealing activity(PubMed:25034436).
Ver Producto
A-Kinase Anchor Protein 8 Like (AKAP8L) Antibody
AKAP8L could play a role in constitutive transport element (CTE) mediated gene expression. Does not seem to be implicated in the binding of regulatory subunit II of PKA. May be involved in nuclear envelope breakdown and chromatin condensation. May regulate the initiation phase of DNA replication when associated with TMPO-beta.
Ver Producto
A-Kinase Anchor Protein 8 Like (AKAP8L) Antibody
AKAP8L Antibody is a Rabbit Polyclonal against AKAP8L.
Ver Producto