A-Kinase Anchor Protein 8 Like (AKAP8L) Antibody
292.5€ (80 µl)
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Name
A-Kinase Anchor Protein 8 Like (AKAP8L) Antibody
Category
Primary Antibodies
Provider
Abbexa
Reference
abx029511
Tested Applications
ELISA, WB
Description
AKAP8L could play a role in constitutive transport element (CTE) mediated gene expression. Does not seem to be implicated in the binding of regulatory subunit II of PKA. May be involved in nuclear envelope breakdown and chromatin condensation. May regulate the initiation phase of DNA replication when associated with TMPO-beta.
Documentos del producto
Instrucciones
Data sheet
Especificaciones del producto
| Category | Primary Antibodies |
| Immunogen Target | Target: A-Kinase Anchor Protein 8 Like (AKAP8L) Immunogen: KLH-conjugated synthetic peptide between 485-512 amino acids from the C-terminal region of human AKAP8L. |
| Host | Rabbit |
| Reactivity | Human, Mouse |
| Recommended Dilution | WB: 1/1000. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Observed MW | Calculated MW: 71.6 kDa |
| Purification | Purified through a protein A column, followed by peptide affinity purification. |
| Size 1 | 80 µl |
| Size 2 | 400 µl |
| Form | Liquid |
| Tested Applications | ELISA, WB |
| Buffer | PBS containing 0.09% sodium azide. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | Q9ULX6 |
| Alias | NAKAP, NAKAP95 |
| Background | Antibody anti-AKAP8L |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |
Background
A Kinase Anchor Protein 8-Like (AKAP8L) is a member of the AKAP family of scaffolding proteins that anchor protein kinase A (PKA) and other signaling molecules to specific subcellular locations, thereby compartmentalizing signaling pathways. AKAP8L is predominantly localized in the nucleus, where it plays a critical role in RNA processing, chromatin remodeling, and transcriptional regulation. It is involved in coordinating events such as mRNA splicing and nuclear export, and it may also contribute to mitotic progression through its interactions with chromatin-associated proteins. AKAP8L facilitates the integration of signaling cascades with gene expression, highlighting its role in cellular adaptation to external and internal cues. Dysregulation of AKAP8L has been implicated in cancer and other diseases, where disrupted nuclear signaling and chromatin dynamics affect cell proliferation and survival. Emerging research suggests AKAP8L’s involvement in stress responses, particularly in modulating nuclear processes under conditions of DNA damage or oxidative stress, making it a potential target for therapeutic intervention.
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