Mouse A-kinase anchor protein 3 (AKAP3) ELISA Kit
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935106861
info@markelab.com
Precio
715€ (96 tests)
Elisa kits for AKAP3
proveedor
Abbexareference
abx501405Tested Applications
ELISAreactivity
Mousestatus
RUOclonality
Descripción
Mouse A-kinase anchor protein 3 (AKAP3) ELISA Kit is an ELISA Kit for the in vitro quantitative measurement of Mouse A-kinase anchor protein 3 concentrations in tissue homogenates, cell lysates and other biological fluids.
Background
AKAP3 is a sperm-specific scaffold protein essential for sperm motility and capacitation. It is highly enriched in the fibrous sheath of the sperm flagellum, where it anchors PKA and other signaling molecules to regulate flagellar function and cAMP signaling. AKAP3 interacts with cAMP-binding proteins, ensuring precise localization of PKA to facilitate phosphorylation events that drive sperm motility and hyperactivation. It is also involved in sperm capacitation, where cAMP signaling leads to biochemical and structural changes necessary for fertilization. AKAP3 mutations or deficiencies impair sperm motility, leading to asthenozoospermia and infertility. Its role in organizing energy production by anchoring mitochondrial proteins highlights its importance in maintaining ATP supply for sperm movement. AKAP3 is also studied as a potential biomarker for male infertility due to its exclusive expression in sperm cells.
Características del producto
category
ELISA Kits
immunogen target
A-kinase anchor protein 3 (AKAP3)
reactivity
Mouse
test range
0.156 ng/ml - 10 ng/ml
assay data
Quantitative
form
Lyophilized
detection method
Colorimetric
sample type
Tissue homogenates, cell lysates and other biological fluids.
size 1
96 tests
alias
Fibrousheathin I,AKAP-3
storage
Shipped at 4 °C. Upon receipt, store the kit according to the storage instruction in the kit's manual.
or code
AKAP3
dry ice
No
uniprot id
note
This product is for research use only. The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments. Please note that our ELISA and CLIA kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein.
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