A-Kinase Anchor Protein 3 (AKAP3) Antibody
364€ (100 µg)
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935106861
info@markelab.com
name
A-Kinase Anchor Protein 3 (AKAP3) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx230255
tested applications
ELISA, WB, IHC
Description
AKAP3 Antibody is a Mouse Monoclonal against AKAP3.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | A-Kinase Anchor Protein 3 (AKAP3) |
| Host | Mouse |
| Reactivity | Human, Mouse |
| Recommended Dilution | WB: 1/500 - 1/2000, IHC: 1/50 - 1/200. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Monoclonal |
| Conjugation | Unconjugated |
| Isotype | IgG2a |
| Purity | ≥ 95% (SDS-PAGE) |
| Purification | Purified by Protein A and Protein G affinity chromatography. |
| Size 1 | 100 µg |
| Form | Liquid |
| Tested Applications | ELISA, WB, IHC |
| Buffer | PBS, pH 7.3, with 0.02% sodium azide and 50% glycerol. |
| Availability | Shipped within 5-12 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | O75969 |
| Gene ID | 10566 |
| OMIM | 604689 |
| Alias | Fibrousheathin I,AKAP-3 |
| Background | Antibody anti-AKAP3 |
| Status | RUO |
| Note | Concentration: 2 mg/ml - Validity: 12 months. |
Descripción
AKAP3 is a sperm-specific scaffold protein essential for sperm motility and capacitation. It is highly enriched in the fibrous sheath of the sperm flagellum, where it anchors PKA and other signaling molecules to regulate flagellar function and cAMP signaling. AKAP3 interacts with cAMP-binding proteins, ensuring precise localization of PKA to facilitate phosphorylation events that drive sperm motility and hyperactivation. It is also involved in sperm capacitation, where cAMP signaling leads to biochemical and structural changes necessary for fertilization. AKAP3 mutations or deficiencies impair sperm motility, leading to asthenozoospermia and infertility. Its role in organizing energy production by anchoring mitochondrial proteins highlights its importance in maintaining ATP supply for sperm movement. AKAP3 is also studied as a potential biomarker for male infertility due to its exclusive expression in sperm cells.
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