Mouse 5-hydroxytryptamine receptor 6 (HTR6) ELISA Kit

Este producto es parte de HTR - 5-Hydroxytryptamine receptors
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715€ (96 tests)

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935106861
info@markelab.com
name
Mouse 5-hydroxytryptamine receptor 6 (HTR6) ELISA Kit
category
ELISA Kits
provider
Abbexa
reference
abx500222
tested applications
ELISA

Description

Mouse 5-hydroxytryptamine receptor 6 (HTR6) ELISA Kit is an ELISA Kit for the in vitro quantitative measurement of Mouse 5-hydroxytryptamine receptor 6 concentrations in tissue homogenates, cell lysates and other biological fluids.

Documents del producto

Instrucciones
Data sheet
Descargar

Product specifications

Category
ELISA Kits
Immunogen Target
5-hydroxytryptamine receptor 6 (HTR6)
Reactivity
Mouse
Detection Method
Colorimetric
Assay Data
Quantitative
Test Range
0.156 ng/ml - 10 ng/ml
Recommended Dilution
Optimal dilutions/concentrations should be determined by the end user.
Size 1
96 tests
Form
Standard Form: Lyophilized
Tested Applications
ELISA
Sample Type
Tissue homogenates, cell lysates and other biological fluids.
Availability
Shipped within 5-15 working days.
Storage
Shipped at 4 °C. Upon receipt, store the kit according to the storage instruction in the kit's manual.
Dry Ice
No
UniProt ID
Q9R1C8
Gene ID
15565
Alias
HTR6,5-HT6. 5-HT6R,5-HT6 receptor
Background
Elisa Kits for: HTR6
Status
RUO
Note
THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES. The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments. Please note that our kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein.
The stability of the kit is determined by the rate of activity loss. The loss rate is less than 5% within the expiration date under appropriate storage conditions. To minimize performance fluctuations, operation procedures and lab conditions should be strictly controlled. It is also strongly suggested that the whole assay is performed by the same user throughout.

Descripción

HTR6 is a G protein-coupled receptor (GPCR) that specifically binds to serotonin (5-HT), activating adenylate cyclase to increase cyclic AMP (cAMP) levels within the cell. This receptor is predominantly expressed in the central nervous system (CNS), particularly in the striatum, cortex, and hippocampus, regions associated with cognition, mood regulation, and motor control. HTR6 plays a critical role in modulating cholinergic signaling, promoting the release of acetylcholine, and enhancing neuronal excitability, which makes it essential for learning and memory processes. Dysregulation of HTR6 has been implicated in several neuropsychiatric and neurodegenerative disorders, including Alzheimer's disease, schizophrenia, and cognitive decline. As such, HTR6 is a target for drug development aimed at improving cognitive function and treating mood disorders. Recent research highlights the receptor’s potential involvement in obesity and metabolic regulation, given its expression in hypothalamic neurons responsible for energy homeostasis. Pharmacological modulation of HTR6 with selective antagonists or agonists holds promise for the treatment of Alzheimer's disease and other cognitive impairments, showcasing its importance in neurological and metabolic health.

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