Mouse 5-hydroxytryptamine receptor 2B (HTR2B) ELISA Kit
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Description
Mouse 5-hydroxytryptamine receptor 2B (HTR2B) ELISA Kit is an ELISA Kit for the in vitro quantitative measurement of Mouse 5-hydroxytryptamine receptor 2B concentrations in tissue homogenates, cell lysates and other biological fluids.
Documents del producto
Product specifications
| Category | ELISA Kits |
| Immunogen Target | 5-hydroxytryptamine receptor 2B (HTR2B) |
| Reactivity | Mouse |
| Detection Method | Colorimetric |
| Assay Data | Quantitative |
| Test Range | 0.156 ng/ml - 10 ng/ml |
| Recommended Dilution | Optimal dilutions/concentrations should be determined by the end user. |
| Size 1 | 96 tests |
| Form | Lyophilized |
| Tested Applications | ELISA |
| Sample Type | Tissue homogenates, cell lysates and other biological fluids. |
| Availability | Shipped within 5-15 working days. The validity for this kit is 6 months. |
| Storage | Shipped at 4 °C. Upon receipt, store the kit according to the storage instruction in the kit's manual. |
| Dry Ice | No |
| UniProt ID | Q02152 |
| Gene ID | 15559 |
| Alias | HTR2B,5-HT2B, 5-HT-2B, 5-HT(2B),5-HT2B receptor |
| Background | Elisa kits for HTR2B |
| Status | RUO |
| Note | Validity: The validity for this kit is 6 months. This product is for research use only. The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments. Please note that our ELISA and CLIA kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein. |
Descripción
HTR2B is another subtype of the G protein-coupled serotonin receptors that modulates diverse physiological functions, including cardiovascular function, smooth muscle contraction, and mood regulation. HTR2B is expressed in the central nervous system (CNS) and peripheral tissues, particularly in the heart, liver, and gastrointestinal tract. In the CNS, it plays a role in mood stabilization and reward processing by regulating the release of neurotransmitters like dopamine. HTR2B is also critical for the development and maintenance of cardiac function, as its activation leads to cardiac hypertrophy and structural remodeling. Dysregulation of HTR2B has been linked to pulmonary hypertension, where its overactivation promotes abnormal vasoconstriction and vascular remodeling. It is also implicated in drug-induced valvular heart disease, particularly from medications like fenfluramine and MDMA (ecstasy), which act as HTR2B agonists. HTR2B’s interaction with serotonergic pathways suggests its relevance in mood disorders, impulsivity, and addiction. Genetic variants in HTR2B have been associated with behavioral abnormalities, such as aggressive impulsivity. Although less studied compared to HTR2A, HTR2B is increasingly recognized as a therapeutic target for cardiovascular disorders, mood stabilization, and conditions involving abnormal serotonin signaling, such as valvular diseases and pulmonary vascular conditions.
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