Mouse 5-Hydroxytryptamine Receptor 1A / 5-HT1A (HTR1A) ELISA Kit

Este producto es parte de HTR - 5-Hydroxytryptamine receptors
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715€ (96 tests)

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935106861
info@markelab.com
name
Mouse 5-Hydroxytryptamine Receptor 1A / 5-HT1A (HTR1A) ELISA Kit
category
ELISA Kits
provider
Abbexa
reference
abx500176
tested applications
ELISA

Description

Mouse 5-hydroxytryptamine receptor 1A (HTR1A) ELISA Kit is an ELISA Kit for the in vitro quantitative measurement of Mouse 5-hydroxytryptamine receptor 1A concentrations in tissue homogenates, cell lysates and other biological fluids.

Documents del producto

Instrucciones
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Data sheet
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Product specifications

Category
ELISA Kits
Immunogen Target
5-Hydroxytryptamine Receptor 1A / 5-HT1A (HTR1A)
Reactivity
Mouse
Detection Method
Colorimetric
Assay Data
Quantitative
Assay Type
Sandwich
Test Range
78 pg/ml - 5000 pg/ml
Sensitivity
< 33 pg/ml
Recommended Dilution
Optimal dilutions/concentrations should be determined by the end user.
Size 1
96 tests
Form
Lyophilized
Tested Applications
ELISA
Sample Type
Tissue homogenates, cell lysates and other biological fluids.
Availability
Shipped within 5-15 working days. The validity for this kit is 6 months.
Storage
Shipped at 4 °C. Upon receipt, store the kit according to the storage instruction in the kit's manual.
Dry Ice
No
UniProt ID
Q64264
Gene ID
15550
Alias
HTR1A,G-21,5HT1a,PFMCD,5-HT1A,5-HT-1A,ADRBRL1,ADRB2RL1,5-HT1A receptor
Background
Elisa kits for HTR1A
Status
RUO
Note
Validity: The validity for this kit is 6 months.
This product is for research use only.   The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments.   Please note that our ELISA and CLIA kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein.

Descripción

HTR1A, a subtype of the serotonin receptor family, is a G protein-coupled receptor (GPCR) responsible for mediating the effects of serotonin (5-HT), a neurotransmitter essential for regulating mood, anxiety, and behavior. Predominantly expressed in the central nervous system, particularly in regions such as the hippocampus, cerebral cortex, and raphe nuclei, HTR1A plays a key role in modulating neuronal excitability and synaptic transmission. Activation of HTR1A leads to the inhibition of adenylyl cyclase, reducing cyclic AMP (cAMP) levels and promoting cellular hyperpolarization, which reduces neuronal firing. Dysregulation of HTR1A has been associated with mood disorders such as depression, anxiety, and schizophrenia, making it a key target for anxiolytic and antidepressant drugs such as SSRIs (selective serotonin reuptake inhibitors) and buspirone. Additionally, HTR1A is involved in neurogenesis, stress response regulation, and cognitive function. Emerging evidence suggests that HTR1A also has neuroprotective properties by reducing oxidative stress, modulating mitochondrial function, and preventing apoptosis in neurons. HTR1A's diverse roles in mood regulation, stress resilience, and cognitive function make it a significant therapeutic target for treating mood disorders, neurodegenerative diseases, and cognitive dysfunction. Ongoing research is investigating its potential for enhancing neuroplasticity and stress resilience in mental health disorders.

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