Methylcytosine Dioxygenase TET1 (TET1) Antibody (HRP)
169€ (20 µg)
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Name
Methylcytosine Dioxygenase TET1 (TET1) Antibody (HRP)
Category
Primary Antibodies
Provider
Abbexa
Reference
abx313738
Tested Applications
ELISA
Description
TET1 Antibody (HRP) is a Rabbit Polyclonal against TET1 conjugated to HRP.
Documentos del producto
Instrucciones
Data sheet
Especificaciones del producto
| Category | Primary Antibodies |
| Immunogen Target | Target: Methylcytosine Dioxygenase TET1 (TET1) Immunogen: Recombinant human Methylcytosine dioxygenase TET1 protein (1700-1800AA). |
| Host | Rabbit |
| Reactivity | Human |
| Recommended Dilution | Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | HRP |
| Isotype | IgG |
| Purity | > 95% |
| Purification | Purified by Protein G. |
| Size 1 | 20 µg |
| Size 2 | 50 µg |
| Size 3 | 100 µg |
| Size 4 | 200 µg |
| Size 5 | 1 mg |
| Form | Liquid |
| Tested Applications | ELISA |
| Buffer | 0.01 M PBS, pH 7.4, 0.03% Proclin-300 and 50% Glycerol. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid exposure to light. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | Q8NFU7 |
| Gene ID | 80312 |
| OMIM | 607790 |
| Alias | CXXC6,LCX,bA119F7.1,CXXC-type zinc finger protein 6,Leukemia-associated protein with a CXXC domain |
| Background | Antibody anti-TET1 |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |
Background
TET1 is a member of the TET protein family that plays a crucial role in DNA demethylation and epigenetic regulation. TET1 catalyzes the conversion of 5-methylcytosine (5mC) to 5-hydroxymethylcytosine (5hmC), an intermediate in the active DNA demethylation pathway, thereby influencing gene expression and chromatin remodeling. TET1 is highly expressed in embryonic stem cells and early development, where it maintains pluripotency, regulates differentiation, and ensures proper gene activation. It functions in tandem with transcription factors and chromatin modifiers to regulate lineage specification, DNA repair, and cellular reprogramming. Dysregulation of TET1 is associated with cancers, including leukemia, where altered DNA methylation patterns contribute to tumorigenesis. Additionally, TET1 is implicated in neurological disorders and aging, where its loss disrupts epigenetic homeostasis. Knockout studies show impaired stem cell self-renewal, aberrant gene silencing, and developmental defects, underscoring TET1's essential role in DNA methylation dynamics, epigenetic reprogramming, and cellular identity maintenance.
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