Methylcytosine Dioxygenase TET1 (TET1) Antibody

Background

TET1 is a member of the TET protein family that plays a crucial role in DNA demethylation and epigenetic regulation. TET1 catalyzes the conversion of 5-methylcytosine (5mC) to 5-hydroxymethylcytosine (5hmC), an intermediate in the active DNA demethylation pathway, thereby influencing gene expression and chromatin remodeling. TET1 is highly expressed in embryonic stem cells and early development, where it maintains pluripotency, regulates differentiation, and ensures proper gene activation. It functions in tandem with transcription factors and chromatin modifiers to regulate lineage specification, DNA repair, and cellular reprogramming. Dysregulation of TET1 is associated with cancers, including leukemia, where altered DNA methylation patterns contribute to tumorigenesis. Additionally, TET1 is implicated in neurological disorders and aging, where its loss disrupts epigenetic homeostasis. Knockout studies show impaired stem cell self-renewal, aberrant gene silencing, and developmental defects, underscoring TET1's essential role in DNA methylation dynamics, epigenetic reprogramming, and cellular identity maintenance.