Metabotropic Glutamate Receptor 5 (GRM5) Antibody (ATTO390)
650€ (100 µg)
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Name
Metabotropic Glutamate Receptor 5 (GRM5) Antibody (ATTO390)
Category
Primary Antibodies
Provider
Abbexa
Reference
abx440167
Tested Applications
WB, IHC, IF/ICC, IP
Description
mGluR1/5 Antibody is a Mouse Monoclonal conjugated to ATTO 390 against mGluR5.
Documentos del producto
Instrucciones
Data sheet
Especificaciones del producto
| Category | Primary Antibodies |
| Immunogen Target | Target: Metabotropic Glutamate Receptor 5 (GRM5) Immunogen: Fusion protein amino acids 824-1203 (cytoplasmic C-terminus) of rat mGluR5b. |
| Host | Mouse |
| Reactivity | Human, Mouse, Rat |
| Detection Method | Laser Line: 390 Excitation/Emission: 390/476 |
| Assay Type | Concentration: 1 mg/ml |
| Recommended Dilution | WB: 1/1000, IHC: 1/1000, IF/ICC: 1/100. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Monoclonal |
| Conjugation | ATTO390 |
| Isotype | IgG1 |
| Purification | Purified by Protein G. |
| Size 1 | 100 µg |
| Tested Applications | WB, IHC, IF/ICC, IP |
| Buffer | PBS, pH 7.4, 50% glycerol, 0.09% sodium azide. |
| Availability | Shipped within 5-12 working days. |
| Storage | Aliquot and store at 4°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | P31424 |
| Gene ID | 24418 |
| NCBI Accession | NP_058708.1 |
| Alias | GRM5,GPRC1E,MGLUR5,PPP1R86,mGlu5 |
| Background | Antibody anti-GRM5 |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |
Background
GRM5, or mGluR5, is a Group I metabotropic glutamate receptor that couples to Gq proteins, activating phospholipase C (PLC), increasing intracellular calcium levels, and triggering downstream signaling pathways such as MAPK and PI3K/Akt. GRM5 is primarily expressed in the hippocampus, cortex, and basal ganglia, where it regulates synaptic plasticity, learning, and memory formation. It also modulates long-term potentiation (LTP) and excitotoxic responses. Dysregulation of GRM5 is implicated in neurological and psychiatric disorders, including fragile X syndrome, autism spectrum disorders (ASD), schizophrenia, and addiction. GRM5 overactivation can exacerbate excitotoxicity, leading to neurodegeneration in diseases like Alzheimer’s and Parkinson’s. Antagonists of GRM5, such as selective negative allosteric modulators (NAMs), are being explored for treating neurodevelopmental disorders, anxiety, and addiction. Targeting GRM5 holds significant promise for improving synaptic function and reducing excitotoxic damage in CNS-related diseases.
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