Melanopsin (OPN4) Antibody

Este producto es parte de OPN - Opsin receptors
Product Graph
221€ (50 µg)

Por favor contáctenos para obtener información detallada sobre el precio y disponibilidad.

935106861
info@markelab.com
name
Melanopsin (OPN4) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx324324
tested applications
ELISA, WB, IF/ICC

Description

OPN4 Antibody is a Rabbit Polyclonal against OPN4.

Documents del producto

Instrucciones
Data sheet
Descargar

Product specifications

Category
Primary Antibodies
Immunogen Target
Melanopsin (OPN4)
Host
Rabbit
Reactivity
Human
Recommended Dilution
ELISA: 1/5000, WB: 1/500 - 1/2000, IF/ICC: 1/200 - 1/1000. Optimal dilutions/concentrations should be determined by the end user.
Clonality
Polyclonal
Conjugation
Unconjugated
Isotype
IgG
Purification
Purified by affinity chromatography.
Size 1
50 µg
Size 2
100 µg
Form
Liquid
Tested Applications
ELISA, WB, IF/ICC
Buffer
PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Availability
Shipped within 5-10 working days.
Storage
Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
Dry Ice
No
UniProt ID
Q9UHM6
Gene ID
94233
OMIM
606665
Alias
OPN4,melanopsin,MOP
Background
Antibody anti-OPN4
Status
RUO
Note
Concentration: 1 mg/ml -

Descripción

Melanopsin, encoded by the OPN4 gene, is a photoreceptor protein primarily found in intrinsically photosensitive retinal ganglion cells (ipRGCs) in the retina. Unlike other opsins, melanopsin is involved in non-visual light responses, such as the regulation of circadian rhythms and the pupillary light reflex. It is sensitive to light in the blue part of the spectrum and plays a significant role in maintaining the body’s internal clock by detecting ambient light and transmitting this information to the brain. This helps to regulate sleep-wake cycles, hormone production, and alertness. In addition to its role in circadian rhythm regulation, melanopsin also contributes to the constriction of the pupil in response to light exposure. Malfunction of melanopsin or its signaling pathways has been associated with circadian rhythm disorders, such as insomnia, as well as mood disorders like depression, particularly seasonal affective disorder. Research into melanopsin's role in light perception and its involvement in circadian biology continues to expand, offering potential therapeutic applications for sleep and mood disorders.

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