Human Melanopsin (OPN4) ELISA Kit
715€ (96 tests)
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935106861
info@markelab.com
name
Human Melanopsin (OPN4) ELISA Kit
category
ELISA Kits
provider
Abbexa
reference
abx518884
tested applications
ELISA
Description
Human Melanopsin (OPN4) ELISA Kit is an ELISA Kit for the in vitro quantitative measurement of Human Melanopsin concentrations in tissue homogenates, cell lysates and other biological fluids.
Documents del producto
Product specifications
| Category | ELISA Kits |
| Immunogen Target | Melanopsin (OPN4) |
| Reactivity | Human |
| Detection Method | Colorimetric |
| Assay Data | Quantitative |
| Assay Type | Sandwich |
| Test Range | 78 pg/ml - 5000 pg/ml |
| Sensitivity | < 41 pg/ml |
| Recommended Dilution | Optimal dilutions/concentrations should be determined by the end user. |
| Size 1 | 96 tests |
| Form | Lyophilized |
| Tested Applications | ELISA |
| Sample Type | Tissue homogenates, cell lysates and other biological fluids. |
| Availability | Shipped within 5-12 working days. The validity for this kit is 6 months. |
| Storage | Shipped at 4 °C. Upon receipt, store the kit according to the storage instruction in the kit's manual. |
| Dry Ice | No |
| UniProt ID | Q9UHM6 |
| Alias | OPN4,melanopsin,MOP |
| Background | Elisa kits for OPN4 |
| Status | RUO |
| Note | Validity: The validity for this kit is 6 months. This product is for research use only. The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments. Please note that our ELISA and CLIA kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein. |
Descripción
Melanopsin, encoded by the OPN4 gene, is a photoreceptor protein primarily found in intrinsically photosensitive retinal ganglion cells (ipRGCs) in the retina. Unlike other opsins, melanopsin is involved in non-visual light responses, such as the regulation of circadian rhythms and the pupillary light reflex. It is sensitive to light in the blue part of the spectrum and plays a significant role in maintaining the body’s internal clock by detecting ambient light and transmitting this information to the brain. This helps to regulate sleep-wake cycles, hormone production, and alertness. In addition to its role in circadian rhythm regulation, melanopsin also contributes to the constriction of the pupil in response to light exposure. Malfunction of melanopsin or its signaling pathways has been associated with circadian rhythm disorders, such as insomnia, as well as mood disorders like depression, particularly seasonal affective disorder. Research into melanopsin's role in light perception and its involvement in circadian biology continues to expand, offering potential therapeutic applications for sleep and mood disorders.
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