Mediator Of DNA Damage Checkpoint 1 Phospho-Ser513 (MDC1 pS513) Antibody
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Description
Rabbit polyclonal antibody against MDC1 protein. Immunogen region is Internal. Specificity is as follows for the reactive species: H:S513.
Documents del producto
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Mediator Of DNA Damage Checkpoint 1 Phospho-Ser513 (MDC1 pS513) |
| Host | Rabbit |
| Reactivity | Human |
| Assay Data | Modification: Phosphorylation // Target Modification: Ser513 |
| Recommended Dilution | IHC: 1/50 - 1/100, ELISA: 1/1000. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Purified from rabbit antiserum by affinity chromatography using epitope-specific immunogen. |
| Size 1 | 10 µg |
| Size 2 | 100 µg |
| Size 3 | 200 µg |
| Size 4 | 300 µg |
| Size 5 | 1 mg |
| Form | Liquid |
| Tested Applications | ELISA, IHC |
| Buffer | PBS (without Mg<sup>2+</sup> and Ca<sup>2+</sup>), pH 7.4, 150 mM NaCl, 0.02% sodium azide, 50% glycerol. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | Q14676 |
| Background | Antibody anti-MDC1 |
| Status | RUO |
| Note | Concentration: 1 mg/ml - |
Descripción
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MDC1 antibody
The protein encoded by this gene contains an N-terminal forkhead domain, two BRCA1 C-terminal (BRCT) motifs and a central domain with 13 repetitions of an approximately 41-amino acid sequence. The encoded protein is required to activate the intra-S phase and G2/M phase cell cycle checkpoints in response to DNA damage. This nuclear protein interacts with phosphorylated histone H2AX near sites of DNA double-strand breaks through its BRCT motifs, and facilitates recruitment of the ATM kinase and meiotic recombination 11 protein complex to DNA damage foci.
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Mediator Of DNA Damage Checkpoint 1 (MDC1) Antibody
MDC1 Antibody is a Rabbit Polyclonal Antibody against MDC1.
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Mediator Of DNA Damage Checkpoint 1 Phospho-Ser513 (MDC1 pS513) Antibody
Rabbit polyclonal antibody against MDC1 protein. Immunogen region is Internal. Specificity is as follows for the reactive species: H:S513.
Ver Producto