MMP17 Antibody is a Rabbit Polyclonal against MMP17.
MMPs are secreted by diverse connective tissue and pro-inflammatory cells. Typically, these enzymes exhibit minimal expression under normal physiological circumstances. MMPs assume a pivotal role in various cellular processes, including cell proliferation, migration, differentiation, angiogenesis, apoptosis, and immunity. They share a common domain structure, consisting of three key components. First is the pro-peptide, which requires removal to activate the enzyme. Next, there is the catalytic domain, featuring a cysteine switch, where a cysteine residue interacts with zinc, and the haemopexin-like C-terminal domain is linked to the catalytic domain via a flexible hinge region. MMP-17, also recognized as membrane-type matrix metalloproteinase 4 (MT-MMP 4), is an enzyme encoded by the MMP17 gene in humans. It is anchored to the cell membrane via a glycosylphosphatidylinositol (GPI) . High expression of this protein has been observed in conditions such as osteoarthritis and multiple human cancers. It also goes by aliases including MT4-MMP, MMP-17, MT4MMP, and MTMMP4.
MMPs son secretadas por diversos tejidos conectivos y células proinflamatorias. Normalmente, estas enzimas exhiben una expresión mínima en circunstancias fisiológicas normales. Las MMP asumen un papel fundamental en diversos procesos celulares, incluida la proliferación, migración, diferenciación, angiogénesis, apoptosis e inmunidad celular. Comparten una estructura de dominio común, que consta de tres componentes clave. El primero es el propéptido, que requiere eliminación para activar la enzima. A continuación, está el dominio catalítico, que presenta un interruptor de cisteína, donde un residuo de cisteína interactúa con el zinc, y el dominio C-terminal similar a hemopexina está unido al dominio catalítico a través de una región bisagra flexible. MMP-17, también reconocida como metaloproteinasa 4 de matriz de tipo membrana (MT-MMP 4), es una enzima codificada por el gen MMP17 en humanos. Está anclado a la membrana celular mediante un anclaje de glicosilfosfatidilinositol (GPI). Se ha observado una expresión elevada de esta proteína en afecciones como la osteoartritis y múltiples cánceres humanos. También tiene alias que incluyen MT4-MMP, MMP-17, MT4MMP y MTMMP4.
Primary Antibodies
Polyclonal
Human
Matrix Metalloproteinase 17 (MMP17)
Rabbit
Unconjugated
Liquid
ELISA, WB
Antigen Affinity Chromatography.
PBS, pH 7.4, containing 0.05% NaN3 and 40% Glycerol.
50 µl
100 µl
Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
MMP17
No
Shipped within 5-10 working days.
This product is for research use only.
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