Human Matrix Metalloproteinase 17 (MMP17) Protein is a Recombinant Human protein expressed in E. coli.
MMPs are secreted by diverse connective tissue and pro-inflammatory cells. Typically, these enzymes exhibit minimal expression under normal physiological circumstances. MMPs assume a pivotal role in various cellular processes, including cell proliferation, migration, differentiation, angiogenesis, apoptosis, and immunity. They share a common domain structure, consisting of three key components. First is the pro-peptide, which requires removal to activate the enzyme. Next, there is the catalytic domain, featuring a cysteine switch, where a cysteine residue interacts with zinc, and the haemopexin-like C-terminal domain is linked to the catalytic domain via a flexible hinge region. MMP-17, also recognized as membrane-type matrix metalloproteinase 4 (MT-MMP 4), is an enzyme encoded by the MMP17 gene in humans. It is anchored to the cell membrane via a glycosylphosphatidylinositol (GPI) . High expression of this protein has been observed in conditions such as osteoarthritis and multiple human cancers. It also goes by aliases including MT4-MMP, MMP-17, MT4MMP, and MTMMP4.
Proteins and Peptides
Human
E. coli
Matrix Metalloproteinase 17 (MMP17)
E. coli
Unconjugated
Lyophilized
WB, SDS-PAGE
1 mg
5 mg
Recombinant
> 90%
Prior to lyophilization: PBS, pH 7.4, containing 0.01% Sarcosyl, 1 mM DTT, 5% Trehalose and Proclin-300.
Store at 2-8 °C for up to one month. Store at -80 °C for up to one year. Avoid repeated freeze/thaw cycles.
MMP17
No
Shipped within 1-2 months.
This product is for research use only. <p></p> Not for human consumption, cosmetic, therapeutic or diagnostic use.
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