Mas-Related G-Protein Coupled Receptor Member X2 (MRGPRX2) Antibody (FITC)
169€ (20 µg)
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Name
Mas-Related G-Protein Coupled Receptor Member X2 (MRGPRX2) Antibody (FITC)
Category
Primary Antibodies
Provider
Abbexa
Reference
abx309379
Description
MRGPRX2 Antibody (FITC) is a Rabbit Polyclonal against MRGPRX2 conjugated to FITC.
Documentos del producto
Instrucciones
Data sheet
Especificaciones del producto
| Category | Primary Antibodies |
| Immunogen Target | Target: Mas-Related G-Protein Coupled Receptor Member X2 (MRGPRX2) Immunogen: Recombinant human Mas-related G-protein coupled receptor member X2 protein (286-330AA). |
| Host | Rabbit |
| Reactivity | Human |
| Detection Method | Laser Line: 488 Excitation/Emission: 499/515 |
| Recommended Dilution | Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | FITC |
| Isotype | IgG |
| Purity | > 95% |
| Purification | Purified by Protein G. |
| Size 1 | 20 µg |
| Size 2 | 50 µg |
| Size 3 | 100 µg |
| Size 4 | 200 µg |
| Size 5 | 1 mg |
| Form | Liquid |
| Buffer | 0.01 M PBS, pH 7.4, 0.03% Proclin-300 and 50% Glycerol. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid exposure to light. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | Q96LB1 |
| Gene ID | 117194 |
| OMIM | 607228 |
| Alias | MRGPRX2,Mrgprb10,MRGX2,MGRG3 |
| Background | Antibody anti-MRGPRX2 |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |
Background
MRGPRX2 is another receptor in the MAS-related GPR family, which is involved in immune and sensory functions. It is primarily expressed in mast cells and sensory neurons, where it contributes to the regulation of allergic reactions and inflammatory responses. MRGPRX2 is activated by endogenous peptides, including substance P, and plays a significant role in mediating the release of histamine from mast cells, leading to allergic symptoms such as itching, swelling, and redness. Additionally, MRGPRX2 has been implicated in pain signaling and neurogenic inflammation. This receptor’s involvement in allergic responses and its ability to modulate mast cell activation makes it a key player in conditions such as asthma, rhinitis, and other allergic disorders. Targeting MRGPRX2 with antagonists offers therapeutic potential for treating allergic conditions and managing symptoms related to mast cell activation.
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