Lysosomal cobalamin transporter ABCD4 (ABCD4) Antibody (Biotin)

Este producto es parte de ABCD - ATP Binding Cassette Transporter D
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260€ (50 µl)

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935106861
info@markelab.com
name
Lysosomal cobalamin transporter ABCD4 (ABCD4) Antibody (Biotin)
category
Primary Antibodies
provider
Abbexa
reference
abx341166
tested applications
ELISA

Description

Lysosomal cobalamin transporter ABCD4 (ABCD4) Antibody (Biotin) is a Rabbit Polyclonal antibody conjugated to Biotin for the detection of Human ABCD4.

Documents del producto

Instrucciones
Data sheet
Descargar

Product specifications

Category
Primary Antibodies
Immunogen Target
Lysosomal cobalamin transporter ABCD4 (ABCD4)
Host
Rabbit
Reactivity
Human
Recommended Dilution
Optimal dilutions/concentrations should be determined by the end user.
Clonality
Polyclonal
Conjugation
Biotin
Isotype
IgG
Purification
Purified by antigen affinity chromatography.
Size 1
50 µl
Size 2
100 µl
Size 3
200 µl
Size 4
1 ml
Form
Liquid
Tested Applications
ELISA
Buffer
0.01 M PBS, pH 7.4, 0.03% Proclin-300 and 50% glycerol.
Availability
Shipped within 5-10 working days.
Storage
Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
Dry Ice
No
UniProt ID
O14678
Gene ID
5826
Alias
ABC41,EST352188,MAHCJ,P70R,P79R
Background
Antibody anti-ABCD4
Status
RUO

Descripción

ABCD4 is a peroxisomal and lysosomal ATP-binding cassette transporter that facilitates the transport of vitamin B12 (cobalamin) across intracellular membranes, enabling its proper processing and utilization. ABCD4 works in conjunction with lysosomal proteins such as LMBD1 to release vitamin B12 from lysosomes into the cytosol, where it is converted into its active forms, methylcobalamin and adenosylcobalamin, essential for DNA synthesis and energy metabolism. Mutations in ABCD4 are associated with cobalamin deficiency type F, which leads to megaloblastic anemia, neurological symptoms, and other metabolic abnormalities. ABCD4 is expressed in various tissues, with critical roles in maintaining vitamin B12 homeostasis and supporting metabolic pathways dependent on this essential cofactor.

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