Lysophosphatidic Acid Receptor 4 (LPAR4) Antibody

Este producto es parte de LPAR - Lysophosphatidic Acid Receptor
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260€ (50 µl)

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935106861
info@markelab.com
name
Lysophosphatidic Acid Receptor 4 (LPAR4) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx214764
tested applications
ELISA, WB, IHC

Description

LPAR4 Antibody is a Rabbit Polyclonal against LPAR4.

Documents del producto

Instrucciones
Data sheet
Descargar

Product specifications

Category
Primary Antibodies
Immunogen Target
Lysophosphatidic Acid Receptor 4 (LPAR4)
Host
Rabbit
Reactivity
Human, Mouse, Rat
Recommended Dilution
ELISA: 1/1000 - 1/5000, WB: 1/500 - 1/2000, IHC: 1/25 - 1/100. Optimal dilutions/concentrations should be determined by the end user.
Clonality
Polyclonal
Conjugation
Unconjugated
Isotype
IgG
Purification
Antigen Affinity Chromatography.
Size 1
50 µl
Size 2
100 µl
Form
Liquid
Tested Applications
ELISA, WB, IHC
Buffer
PBS, pH 7.4, containing 0.05% NaN3 and 40% Glycerol.
Availability
Shipped within 5-10 working days.
Storage
Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
Dry Ice
No
UniProt ID
Q99677
Gene ID
2846
Alias
LPAR4,GPR23,LPA4,P2RY9,P2Y5-LIKE,P2Y9,P2Y5-like receptor,G protein-coupled receptor 23,LPA receptor 4,P2Y,purinoceptor 9,Purinergic receptor 9
Background
Antibody anti-LPAR4
Status
RUO

Descripción

LPAR4 is a G protein-coupled receptor for lysophosphatidic acid (LPA) that preferentially couples to G12/13 and Gq proteins, influencing cytoskeletal organization, calcium signaling, and cell migration. LPAR4 is expressed in hematopoietic cells, endothelial cells, and certain epithelial tissues, where it regulates cell adhesion, proliferation, and vascular development. Unlike other LPA receptors, LPAR4 has been implicated in blood vessel stability and lymphocyte trafficking, playing a role in vascular homeostasis and immune cell regulation. LPAR4 activation contributes to endothelial barrier function and vascular remodeling, making it relevant in conditions such as vascular inflammation and atherosclerosis. In cancer, LPAR4’s role is less well characterized compared to other LPA receptors, but it has been linked to cell migration and metastasis in certain malignancies. Dysregulation of LPAR4 signaling is associated with vascular disorders and immune dysfunction. Targeting LPAR4 offers therapeutic potential for vascular diseases, immune modulation, and cancer progression, highlighting its emerging role in LPA-mediated signaling pathways.

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