Lysophosphatidic Acid Receptor 4 (LPAR4) Antibody
260€ (50 µl)
260€ (50 µl)
Por favor contáctenos para obtener información detallada sobre el precio y disponibilidad.
935106861
info@markelab.com
name
Lysophosphatidic Acid Receptor 4 (LPAR4) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx214764
tested applications
ELISA, WB, IHC
Descripción del producto
LPAR4 Antibody is a Rabbit Polyclonal against LPAR4.
Documents del producto
Instrucciones
Data sheet
Especificaciones del producto
| Alias | LPAR4,GPR23,LPA4,P2RY9,P2Y5-LIKE,P2Y9,P2Y5-like receptor,G protein-coupled receptor 23,LPA receptor 4,P2Y,purinoceptor 9,Purinergic receptor 9 |
| Availability | Shipped within 5-10 working days. |
| Background | Antibody anti-LPAR4 |
| Buffer | PBS, pH 7.4, containing 0.05% NaN3 and 40% Glycerol. |
| Category | Primary Antibodies |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Dry Ice | No |
| Form | Liquid |
| Gene ID | 2846 |
| Host | Rabbit |
| Immunogen Target | Lysophosphatidic Acid Receptor 4 (LPAR4) |
| Isotype | IgG |
| Name | Lysophosphatidic Acid Receptor 4 (LPAR4) Antibody |
| Price | 260 |
| Provider | Abbexa |
| Purification | Antigen Affinity Chromatography. |
| Reactivity | Human, Mouse, Rat |
| Recommended Dilution | ELISA: 1/1000 - 1/5000, WB: 1/500 - 1/2000, IHC: 1/25 - 1/100. Optimal dilutions/concentrations should be determined by the end user. |
| Reference | abx214764 |
| Size 1 | 50 µl |
| Size 2 | 100 µl |
| Status | RUO |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Tested Applications | ELISA, WB, IHC |
| UniProt ID | Q99677 |
Descripcion del producto en español
Background en español
LPAR4 is a G protein-coupled receptor for lysophosphatidic acid (LPA) that preferentially couples to G12/13 and Gq proteins, influencing cytoskeletal organization, calcium signaling, and cell migration. LPAR4 is expressed in hematopoietic cells, endothelial cells, and certain epithelial tissues, where it regulates cell adhesion, proliferation, and vascular development. Unlike other LPA receptors, LPAR4 has been implicated in blood vessel stability and lymphocyte trafficking, playing a role in vascular homeostasis and immune cell regulation. LPAR4 activation contributes to endothelial barrier function and vascular remodeling, making it relevant in conditions such as vascular inflammation and atherosclerosis. In cancer, LPAR4’s role is less well characterized compared to other LPA receptors, but it has been linked to cell migration and metastasis in certain malignancies. Dysregulation of LPAR4 signaling is associated with vascular disorders and immune dysfunction. Targeting LPAR4 offers therapeutic potential for vascular diseases, immune modulation, and cancer progression, highlighting its emerging role in LPA-mediated signaling pathways.
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Receptor for lysophosphatidic acid(LPA), a mediator of diverse cellular activities. Transduces a signal by increasing the intracellular calcium ions and by stimulating adenylyl cyclase activity. The rank order of potency for agonists of this receptor is 1-oleoyl-> 1-stearoyl-> 1-palmitoyl-> 1-myristoyl-> 1-alkyl-> 1-alkenyl-LPA.
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