LRIT3 Antibody
357.5€ (100 µg)
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name
LRIT3 Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx146229
tested applications
ELISA, WB
Description
LRIT3 Antibody is a Rabbit Polyclonal against LRIT3.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | LRIT3 |
| Host | Rabbit |
| Reactivity | Human |
| Recommended Dilution | ELISA: 1/20000 - 1/80000, WB: 1/500 - 1/2000. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Purified by antigen affinity column chromatography. |
| Size 1 | 100 µg |
| Size 2 | 1 mg |
| Form | Lyophilized |
| Tested Applications | ELISA, WB |
| Buffer | Prior to lyophilization: 1% BSA and 0.02% NaN3. |
| Availability | Shipped within 7-15 working days. |
| Storage | Store at -20 °C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| NCBI Accession | BC104037 |
| Alias | CSNB1F,FIGLER4,Leucine-rich repeat, immunoglobulin-like domain and transmembrane domain-containing protein 3 |
| Background | Antibody anti-LRIT3 |
| Status | RUO |
| Note | Concentration: Lyophilized form: Not applicable. After reconstitution: 1 mg/ml. - |
Descripción
LRIT3 shares structural similarities with LRIT1, including its LRR and Ig-like domains, and plays a critical role in the proper functioning of retinal bipolar cells. LRIT3 is expressed specifically in the retina, where it is essential for the transmission of visual signals from photoreceptors to downstream neurons. Mutations in the LRIT3 gene are associated with autosomal recessive complete congenital stationary night blindness (cCSNB), which is characterized by impaired visual signal transmission despite normal photoreceptor activity. LRIT3 functions as a scaffold for synaptic proteins, ensuring proper synaptic architecture and signal fidelity within the retina. Its involvement in modulating postsynaptic responses underscores its significance in visual sensory processing.
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