LPAR6 Antibody

292.5€ (80 µl)
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935106861
info@markelab.com
name
LPAR6 Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx026968
tested applications
ELISA, WB, IHC
Description
The protein encoded by this gene belongs to the family of G-protein coupled receptors, that are preferentially activated by adenosine and uridine nucleotides. This gene aligns with an internal intron of the retinoblastoma susceptibility gene in the reverse orientation. Alternative splicing results in multiple transcript variants.
Documents del producto
Instrucciones
Data sheet
Product specifications
Category | Primary Antibodies |
Immunogen Target | LPAR6 |
Host | Rabbit |
Reactivity | Human, Mouse, Rat |
Recommended Dilution | WB: 1/1000, IHC-P: 1/10 - 1/50. Not tested in IHC-F. Optimal dilutions/concentrations should be determined by the end user. |
Clonality | Polyclonal |
Conjugation | Unconjugated |
Isotype | IgG |
Purification | Purified through a protein A column, followed by peptide affinity purification. |
Size 1 | 80 µl |
Size 2 | 400 µl |
Form | Liquid |
Tested Applications | ELISA, WB, IHC |
Buffer | PBS containing 0.09% sodium azide. |
Availability | Shipped within 5-10 working days. |
Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
Dry Ice | No |
UniProt ID | P43657 |
Alias | LPAR6,ARWH1,HYPT8,LAH3,LPA-6,P2RY5,P2Y5,LPA receptor 6,oleoyl-L-alpha-lysophosphatidic acid receptor,P2Y purinoceptor 5,purinergic receptor 5 |
Background | Antibody anti-LPAR6 |
Status | RUO |
Descripción
LPAR6, also known as P2Y5, is a G protein-coupled receptor activated by lysophosphatidic acid (LPA). It primarily couples to G12/13 proteins and plays a key role in cellular signaling related to cytoskeletal reorganization, cell migration, and proliferation. LPAR6 is predominantly expressed in hair follicles, skin, and epithelial tissues, where it regulates hair growth and skin homeostasis. Mutations in LPAR6 are associated with inherited hair disorders such as hypotrichosis and woolly hair syndrome, where impaired LPA signaling disrupts normal hair follicle function. Beyond its role in hair biology, LPAR6 contributes to epithelial cell survival and wound healing processes. LPAR6 has also been linked to cancer progression, particularly in promoting cell migration, metastasis, and resistance to apoptosis in epithelial cancers. Dysregulation of LPAR6 signaling has implications in skin disorders, inflammatory conditions, and tumor progression. LPAR6 represents a therapeutic target for managing hair growth disorders, epithelial repair, and cancer metastasis.
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