LIM And Senescent Cell Antigen Like Domains Protein 1 (LIMS1) Antibody (HRP)
169€ (20 µg)
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Name
LIM And Senescent Cell Antigen Like Domains Protein 1 (LIMS1) Antibody (HRP)
Category
Primary Antibodies
Provider
Abbexa
Reference
abx336372
Tested Applications
ELISA
Description
LIMS1 Antibody (HRP) is a Rabbit Polyclonal against LIMS1.
Documentos del producto
Instrucciones
Data sheet
Especificaciones del producto
| Category | Primary Antibodies |
| Immunogen Target | Target: LIM And Senescent Cell Antigen Like Domains Protein 1 (LIMS1) Immunogen: Recombinant Human LIM and senescent cell antigen-like-containing domain protein 1 protein (1-325AA). |
| Host | Rabbit |
| Reactivity | Human |
| Recommended Dilution | Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | HRP |
| Isotype | IgG |
| Purity | > 95% |
| Purification | Purified by Protein G. |
| Size 1 | 20 µg |
| Size 2 | 50 µg |
| Size 3 | 100 µg |
| Size 4 | 200 µg |
| Size 5 | 1 mg |
| Form | Liquid |
| Tested Applications | ELISA |
| Buffer | 0.01 M PBS, pH 7.4, 0.03% Proclin-300 and 50% Glycerol. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid exposure to light. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | P48059 |
| Gene ID | 3987 |
| Alias | LIMS1,PINCH,INCH1,PINCH-1,LIM and senescent cell antigen-like-containing domain protein 1 |
| Background | Antibody anti-LIMS1 |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |
Background
LIMS1, also known as PINCH1 (Particularly Interesting New Cysteine-Histidine rich protein), is a LIM domain-containing adaptor protein involved in integrin-mediated cell adhesion and signaling. LIMS1 interacts with focal adhesion proteins such as ILK (integrin-linked kinase) and acts as a scaffold to regulate cell-ECM adhesion, cytoskeletal organization, and signaling pathways like PI3K/Akt, MAPK/ERK, and TGF-β. It is broadly expressed in tissues and plays critical roles in cell survival, migration, differentiation, and embryonic development. LIMS1 is essential for cardiac and skeletal muscle development, where it stabilizes focal adhesions and modulates mechanical signaling. Dysregulation of LIMS1 is associated with cancer progression, metastasis, and fibrosis due to its role in integrin signaling and actin cytoskeleton remodeling. Knockout models show embryonic lethality, severe developmental defects, and impaired adhesion, highlighting its importance in tissue homeostasis.
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