Leukocyte Antigen CD37 / TSPAN26 (CD37) Antibody
383.5€ (100 µl)
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Name
Leukocyte Antigen CD37 / TSPAN26 (CD37) Antibody
Category
Primary Antibodies
Provider
Abbexa
Reference
abx010524
Tested Applications
ELISA, IF/ICC
Description
CD37, also known as GP52-40, TSPAN26, MGC120234. Enterz Protein NP001035120. It is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. This encoded protein is a cell surface glycoprotein that is known to complex with integrins and other transmembrane 4 superfamily proteins. It may play a role in T-cell-B-cell interactions. Alternate splicing results in multiple transcript variants encoding different isoforms.
Documentos del producto
Instrucciones
Data sheet
Especificaciones del producto
| Category | Primary Antibodies |
| Immunogen Target | Target: Leukocyte Antigen CD37 / TSPAN26 (CD37) Immunogen: Purified recombinant fragment of CD37 expressed in E. coli. |
| Host | Mouse |
| Reactivity | Human, Mouse |
| Assay Type | Concentration: Not determined. |
| Recommended Dilution | ELISA: 1/10000, IF/ICC: 1/200 - 1/1000. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Monoclonal |
| Conjugation | Unconjugated |
| Isotype | IgG1 |
| Observed MW | 31.7 kDa |
| Purification | Unpurified ascites. |
| Size 1 | 100 µl |
| Form | Liquid |
| Tested Applications | ELISA, IF/ICC |
| Buffer | Ascitic fluid containing 0.03% sodium azide. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | P11049 |
| Gene ID | 951 |
| Alias | GP52-40,TSPAN26,Leukocyte antigen CD37,Tetraspanin-26 |
| Background | Antibody anti-CD37 |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |
Background
CD37 is a member of the tetraspanin family, a group of membrane proteins involved in cellular signaling, adhesion, migration, and immune responses. It is primarily expressed on leukocytes, especially on B cells, T cells, monocytes, and dendritic cells. CD37 plays a pivotal role in organizing membrane microdomains called tetraspanin-enriched microdomains (TEMs), which serve as platforms for cell signaling, facilitating the clustering of various membrane proteins, including integrins and other receptors involved in immune regulation. Unlike many other surface molecules, tetraspanins such as CD37 do not have a direct catalytic function but modulate the function of other molecules by influencing their spatial distribution and assembly in the membrane. This modulation affects immune cell functions, such as antigen presentation, cell adhesion, and migration, as well as B cell maturation and antibody production.
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